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Articles Published Processes
6/25/2026 8:21:22 AM | Browse: 0 | Download: 0
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Received |
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2026-03-03 10:39 |
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Peer-Review Started |
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2026-03-03 10:39 |
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First Decision by Editorial Office Director |
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2026-03-17 07:31 |
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Return for Revision |
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2026-03-17 07:31 |
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Revised |
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2026-03-31 12:06 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-04-27 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-07 07:28 |
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Articles in Press |
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2026-05-07 07:28 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-15 10:04 |
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Publish the Manuscript Online |
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2026-06-25 08:21 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
ENaCδ aggravates gastroesophageal reflux disease via PI3K/AKT/mTOR: Human umbilical cord mesenchymal stem cells restore barrier function
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cong Wang, Yi Li, Qian-Qian Chen and Jun Wan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Beijing Natural Science Foundation |
7232151 |
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| Corresponding Author |
Jun Wan, MD, Department of Gastroenterology, The Second Medical Center of Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. wanjun_301@126.com |
| Key Words |
Human umbilical cord mesenchymal stem cells; Gastroesophageal reflux disease; Humanized epithelial sodium channel δ mouse model; Epithelial sodium channel; Proton pump inhibitor |
| Core Tip |
We developed a CRISPR/Cas9-generated humanized epithelial sodium channel δ mouse model to better mimic human gastroesophageal reflux disease. Humanized epithelial sodium channel δ aggravated acid-induced esophageal inflammation by activating the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathway, increasing interleukin 1 (IL-1), IL-1β, IL-17 and inducible nitric oxide synthase, and impairing barrier and contractile regulators (claudin-1 and myosin phosphatase target subunit 1). Human umbilical cord mesenchymal stem cells reversed these changes and outperformed proton pump inhibitor in suppressing IL-17 and restoring claudin-1/myosin phosphatase target subunit 1. |
| Publish Date |
2026-06-25 08:21 |
| Citation |
Wang C, Li Y, Chen QQ, Wan J. ENaCδ aggravates gastroesophageal reflux disease via PI3K/AKT/mTOR: Human umbilical cord mesenchymal stem cells restore barrier function. World J Stem Cells 2026; 18(6): 120457
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i6/120457.htm |
| DOI |
https://doi.org/10.4252/wjsc.120457 |
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