7/13/2026 9:40:36 AM | Browse: 3 | Download: 1
| Publication Name | World Journal of Gastrointestinal Oncology |
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| Manuscript ID | 120469 |
| Country | Germany |
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| ISSN | 1948-5204 (online) |
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| Open Access | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright | ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 |
| Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 |
| Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website | http://www.wjgnet.com |
| Category | Gastroenterology & Hepatology | ||||||
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| Manuscript Type | Retrospective Study | ||||||
| Article Title | Prognostic significance of germline ARID5B and LEPR polymorphisms in intrahepatic and perihilar cholangiocarcinoma after curative resection | ||||||
| Manuscript Source | Unsolicited Manuscript | ||||||
| All Author List | Guanwu Wang, Carlos Otto, Dong Liu, Tarick M Al-Masri, Smiths S Lueong, Jens Siveke, Tom Luedde, Daniel Heise, Florian WR Vondran, Franziska Alexandra Meister, Georg Lurje, Ulf Neumann, Lara Heij and Jan Bednarsch | ||||||
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| Corresponding Author | Jan Bednarsch, Department of Surgery and Transplantation, University Hospital Essen, Hufelandstrasse 55, Essen 45147, North Rhine-Westphalia, Germany. jan.bednarsch@uk-essen.de | ||||||
| Key Words | Cholangiocarcinoma; Single-nucleotide polymorphisms; ARID5B; LEPR; Prognostic biomarker | ||||||
| Core Tip | This study identifies germline ARID5B rs10740055 and LEPR rs1137101 polymorphisms as prognostic biomarkers in patients undergoing curative resection for intrahepatic and perihilar cholangiocarcinoma. In a cohort of 229 patients, the ARID5B rs10740055 AA genotype was consistently associated with significantly worse recurrence-free, cancer-specific, and overall survival, serving as an independent predictor particularly in intrahepatic cholangiocarcinoma. The LEPR rs1137101 GG genotype was additionally associated with shorter recurrence-free survival in intrahepatic tumors. These findings highlight the potential value of incorporating host genetic variants into postoperative risk stratification and personalized management strategies for cholangiocarcinoma. | ||||||
| Publish Date | 2026-07-13 09:40 | ||||||
| Citation |
Wang G, Otto C, Liu D, Al-Masri TM, Lueong SS, Siveke J, Luedde T, Heise D, Vondran FW, Meister FA, Lurje G, Neumann U, Heij L, Bednarsch J. Prognostic significance of germline ARID5B and LEPR polymorphisms in intrahepatic and perihilar cholangiocarcinoma after curative resection. World J Gastrointest Oncol 2026; 18(7): 120469 |
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| URL | https://www.wjgnet.com/1948-5204/full/v18/i7/120469.htm | ||||||
| DOI | https://doi.org/10.4251/wjgo.120469 |
| Full Article (PDF) | WJGO-18-120469-with-cover.pdf |
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| Manuscript File | 120469_Auto_Edited_074750.docx |
| Answering Reviewers | 120469-answering-reviewers.pdf |
| Audio Core Tip | 120469-audio.mp3 |
| Biostatistics Review Certificate | 120469-biostatistics-statement.pdf |
| Conflict-of-Interest Disclosure Form | 120469-conflict-of-interest-statement.pdf |
| Copyright License Agreement | 120469-copyright-assignment.pdf |
| Signed Informed Consent Form(s) or Document(s) | 120469-informed-consent-statement.pdf |
| Institutional Review Board Approval Form or Document | 120469-institutional-review-board-statement.pdf |
| Non-Native Speakers of English Editing Certificate | 120469-non-native-speakers.pdf |
| Supplementary Material | 120469-supplementary-material.pdf |
| Peer-review Report | 120469-peer-reviews.pdf |
| Scientific Misconduct Check | 120469-scientific-misconduct-check.png |
| Scientific Editor Work List | 120469-scientific-editor-work-list.pdf |
| CrossCheck Report | 120469-crosscheck-report.pdf |