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Articles Published Processes
9/9/2026 9:45:07 AM | Browse: 1 | Download: 0
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Received |
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2026-02-27 01:30 |
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Peer-Review Started |
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2026-02-27 01:30 |
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First Decision by Editorial Office Director |
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2026-03-13 08:06 |
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Return for Revision |
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2026-03-13 08:06 |
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Revised |
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2026-03-25 17:21 |
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Publication Fee Transferred |
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2026-06-24 21:06 |
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Second Decision by Editor |
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2026-07-28 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-07-28 13:31 |
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Articles in Press |
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2026-07-28 13:31 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-24 00:23 |
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Publish the Manuscript Online |
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2026-09-09 09:45 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Dietary eicosapentaenoic and docosahexaenoic acids decrease prostanoids in the ileum of rats treated with irinotecan and 5-fluorouracil
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sarah R Parsons, Irma M Rivas-Serna, M Thomas Clandinin and Vera C Mazurak |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Canadian Institutes of Health Research |
No. PS165820 |
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| Corresponding Author |
Vera C Mazurak, Professor, Department of Agricultural, Food and Nutritional Science, University of Alberta, 4-002F Li Ka Shing Centre for Health Research, Edmonton T6G 2P5, Alberta, Canada. vmazurak@ualberta.ca |
| Key Words |
Ileum; Oxylipins; Phospholipid fatty acids; Rat; Tumor; Chemotherapy; Colorectal cancer; N-3 fatty acids; Fish oil; Irinotecan |
| Core Tip |
The present study is the first to investigate n-6- and n-3-derived oxylipin levels from ileum tissue after irinotecan + 5-fluorouracil and modification by dietary eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The arachidonic acid (AA) metabolite 6-keto-prostaglandin F1α implicated in inhibiting water absorption and electrolyte dysregulation increased after irinotecan + 5-fluorouracil. Dietary EPA and DHA markedly reduced 6-keto-prostaglandin F1α and several other prostanoids while increasing protective and resolving mediators, lipoxin A4 (AA-derived) and protectin-D1 (DHA-derived). Oxylipin potential to reduce the risk of chemotherapy-induced adverse effects, such as diarrhea, should be explored in models of multi-cycle chemotherapy. |
| Publish Date |
2026-09-09 09:45 |
| Citation |
Parsons SR, Rivas-Serna IM, Clandinin MT, Mazurak VC. Dietary eicosapentaenoic and docosahexaenoic acids decrease prostanoids in the ileum of rats treated with irinotecan and 5-fluorouracil. World J Gastrointest Oncol 2026; 18(9): 120472
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i9/120472.htm |
| DOI |
https://doi.org/10.4251/wjgo.120472 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
