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Articles Published Processes
8/19/2026 1:55:07 AM | Browse: 1 | Download: 0
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Received |
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2026-03-17 10:10 |
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Peer-Review Started |
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2026-03-17 10:10 |
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First Decision by Editorial Office Director |
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2026-03-27 02:45 |
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Return for Revision |
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2026-03-27 02:45 |
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Revised |
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2026-04-07 09:22 |
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Publication Fee Transferred |
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2026-04-11 02:46 |
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Second Decision by Editor |
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2026-05-12 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-12 08:02 |
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Articles in Press |
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2026-05-12 08:02 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-11 02:38 |
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Publish the Manuscript Online |
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2026-08-19 01:55 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pediatrics |
| Manuscript Type |
Basic Study |
| Article Title |
Lactation stage-dependent protective effects of human milk exosomes against intestinal ischemia-reperfusion injury via lactoferrin/lysozyme-mediated Nrf2/HO-1 and NF-κB pathways
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Guang Yang and Li Liu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Li Liu, MD, Professor, Department of Neonatology, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta West Road, Yanta District, Xi’an 710061, Shaanxi Province, China. liuli918@163.com |
| Key Words |
Human milk exosomes; Intestinal ischemia-reperfusion injury; Lactoferrin; Lysozyme; Nuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathway; Nuclear factor kappa B pathway |
| Core Tip |
This study demonstrates that human milk exosomes protect against intestinal ischemia-reperfusion injury in a lactation stage-dependent manner. Colostrum exosomes, rich in lactoferrin and lysozyme, exhibit optimal protection by activating the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 antioxidant pathway and inhibiting the nuclear factor kappa B inflammatory pathway. These findings provide a basis for developing exosome-based therapies for neonatal gut injury. |
| Publish Date |
2026-08-19 01:55 |
| Citation |
Yang G, Liu L. Lactation stage-dependent protective effects of human milk exosomes against intestinal ischemia-reperfusion injury via lactoferrin/lysozyme-mediated Nrf2/HO-1 and NF-κB pathways. World J Gastroenterol 2026; 32(34): 120518
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i34/120518.htm |
| DOI |
https://doi.org/10.3748/wjg.v32.i34.120518 |
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