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Articles Published Processes
5/19/2026 7:13:10 AM | Browse: 0 | Download: 0
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Received |
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2026-03-09 03:34 |
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Peer-Review Started |
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2026-03-09 03:35 |
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First Decision by Editorial Office Director |
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2026-03-20 10:46 |
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Return for Revision |
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2026-03-20 10:46 |
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Revised |
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2026-04-01 11:29 |
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Publication Fee Transferred |
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2026-04-27 13:57 |
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Second Decision by Editor |
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2026-04-24 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-24 06:58 |
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Articles in Press |
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2026-04-24 06:58 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-13 00:23 |
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Publish the Manuscript Online |
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2026-05-19 07:13 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
S1PR1 knockdown protects endothelial cells from oxidized low-density lipoprotein-induced injury via reducing interleukin-1β and tumor necrosis factor-α expression
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fu-Ying Chu, Meng-Han Yao, Le-Ming Gu, Hua Cai, Ya-Nan Li, Xiang Chen and Xin-Xin Xu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Wu Jieping Medical Foundation |
320.6750.2024-03-70 |
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| Corresponding Author |
Xin-Xin Xu, Department of Laboratory Medicine, Affiliated Hospital of Nantong University, No. 20 Xisi Road, Chongchuan District, Nantong 226000, Jiangsu Province, China. xxxin891119@163.com |
| Key Words |
Sphingosine-1-phosphate receptor 1; Coronary atherosclerotic heart disease; Oxidized low-density lipoprotein; Interleukin-1β; Tumor necrosis factor-α |
| Core Tip |
In this study, sphingosine-1-phosphate receptor 1 (S1PR1) is upregulated in coronary atherosclerotic heart disease and positively correlates with interleukin-1β and tumor necrosis factor-α. It serves as a promising diagnostic biomarker, and combined detection with inflammatory cytokines enhances diagnostic performance. S1PR1 knockdown alleviates oxidized low-density lipoprotein-induced endothelial cell injury via modulating inflammatory responses, highlighting S1PR1 as a potential target for coronary atherosclerotic heart disease diagnosis and intervention. |
| Publish Date |
2026-05-19 07:13 |
| Citation |
Chu FY, Yao MH, Gu LM, Cai H, Li YN, Chen X, Xu XX. S1PR1 knockdown protects endothelial cells from oxidized low-density lipoprotein-induced injury via reducing interleukin-1β and tumor necrosis factor-α expression. World J Cardiol 2026; 18(5): 120519 |
| URL |
https://www.wjgnet.com/1949-8462/full/v18/i5/120519.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v18.i5.120519 |
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