Publication Name	World Journal of Hepatology
Manuscript ID	12052
Country	United States

Received	2014-06-19 20:23
Peer-Review Started	2014-06-20 21:39
To Make the First Decision	2014-07-10 17:27
Return for Revision	2014-07-17 22:38
Revised	2014-07-22 11:25
Second Decision	2014-11-12 13:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-11-19 11:07
Articles in Press	2014-11-19 11:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-25 09:54
Publish the Manuscript Online	2015-01-10 16:31

ISSN	1948-5182 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Hagen-Poiseuille’s law: The link between cirrhosis, liver stiffness, portal hypertension and hepatic decompensation
Manuscript Source	Invited Manuscript
All Author List	Gerond Lake-Bakaar, Muneeb Ahmed, Amy Evenson, Alan Bonder, Salomao Faintuch and Vinay Sundaram
Funding Agency and Grant Number
Corresponding Author	Gerond Lake-Bakaar, MD, PhD, Liver Tumor Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis Street, Suite 7A-055, Boston, MA 02215, United States. glakebak@bidmc.harvard.edu
Key Words	Portal hypertension; Liver stiffness; Hagen-Poiseuille’s law
Core Tip	Unlike the elastic normal liver, hepatic sinusoidal vessels become progressively more rigid with advancing cirrhosis and thus subject to Hagen-Poiseuille’s law. Thereafter, pressure gradient is inversely proportional to the fourth power of vessel radius, r4. Surgical resection reduces liver volume and thus net diameter of sinusoids, without reducing hepatic blood inflow. The net reduction in r, at the same flow rates increases pressure gradient by a factor r4 and likely accounts for the poor outcomes in patients with cirrhosis and established portal hypertension. Reducing hepatic venous pressure gradient reduction as part of the management of cirrhosis may reduce the risk of decompensation.
Publish Date	2015-01-10 16:31
Citation	Lake-Bakaar G, Ahmed M, Evenson A, Bonder A, Faintuch S, Sundaram V. Hagen-Poiseuille’s law: The link between cirrhosis, liver stiffness, portal hypertension and hepatic decompensation. World J Hepatol 2015; 7(1): 28-32
URL	http://www.wjgnet.com/1948-5182/full/v7/i1/28.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i1.28

Full Article (PDF)	WJH-7-28.pdf
Full Article (Word)	WJH-7-28.doc
Manuscript File	12052-Review.doc
Answering Reviewers	12052-Answering reviewers.pdf
Copyright License Agreement	12052-Copyright assignment.pdf
Peer-review Report	12052-Peer review(s).pdf
Scientific Misconduct Check	12052-CrossCheck.jpg
Scientific Editor Work List	12052-Scientific editor work list.pdf