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1/10/2015 4:31:00 PM | Browse: 598 | Download: 434
Publication Name World Journal of Hepatology
Manuscript ID 12052
Country/Territory United States
Received
2014-06-19 20:23
Peer-Review Started
2014-06-20 21:39
To Make the First Decision
2014-07-10 17:27
Return for Revision
2014-07-17 22:38
Revised
2014-07-22 11:25
Second Decision
2014-11-12 13:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-11-19 11:07
Articles in Press
2014-11-19 11:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-12-25 09:54
Publish the Manuscript Online
2015-01-10 16:31
ISSN 1948-5182 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Topic Highlights
Article Title Hagen-Poiseuille’s law: The link between cirrhosis, liver stiffness, portal hypertension and hepatic decompensation
Manuscript Source Invited Manuscript
All Author List Gerond Lake-Bakaar, Muneeb Ahmed, Amy Evenson, Alan Bonder, Salomao Faintuch and Vinay Sundaram
Funding Agency and Grant Number
Corresponding Author Gerond Lake-Bakaar, MD, PhD, Liver Tumor Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis Street, Suite 7A-055, Boston, MA 02215, United States. glakebak@bidmc.harvard.edu
Key Words Portal hypertension; Liver stiffness; Hagen-Poiseuille’s law
Core Tip Unlike the elastic normal liver, hepatic sinusoidal vessels become progressively more rigid with advancing cirrhosis and thus subject to Hagen-Poiseuille’s law. Thereafter, pressure gradient is inversely proportional to the fourth power of vessel radius, r4. Surgical resection reduces liver volume and thus net diameter of sinusoids, without reducing hepatic blood inflow. The net reduction in r, at the same flow rates increases pressure gradient by a factor r4 and likely accounts for the poor outcomes in patients with cirrhosis and established portal hypertension. Reducing hepatic venous pressure gradient reduction as part of the management of cirrhosis may reduce the risk of decompensation.
Publish Date 2015-01-10 16:31
Citation Lake-Bakaar G, Ahmed M, Evenson A, Bonder A, Faintuch S, Sundaram V. Hagen-Poiseuille’s law: The link between cirrhosis, liver stiffness, portal hypertension and hepatic decompensation. World J Hepatol 2015; 7(1): 28-32
URL http://www.wjgnet.com/1948-5182/full/v7/i1/28.htm
DOI http://dx.doi.org/10.4254/wjh.v7.i1.28
Full Article (PDF) WJH-7-28.pdf
Full Article (Word) WJH-7-28.doc
Manuscript File 12052-Review.doc
Answering Reviewers 12052-Answering reviewers.pdf
Copyright License Agreement 12052-Copyright assignment.pdf
Peer-review Report 12052-Peer review(s).pdf
Scientific Misconduct Check 12052-CrossCheck.jpg
Scientific Editor Work List 12052-Scientific editor work list.pdf