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Articles Published Processes
1/27/2015 3:33:00 PM | Browse: 1300 | Download: 1557
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Received |
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2014-06-19 20:19 |
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Peer-Review Started |
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2014-06-20 20:21 |
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To Make the First Decision |
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2014-07-21 13:31 |
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Return for Revision |
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2014-07-28 15:05 |
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Revised |
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2014-09-09 00:00 |
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Second Decision |
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2014-10-15 07:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-10-15 08:10 |
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Articles in Press |
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2014-10-15 08:25 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-01-14 14:21 |
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Publish the Manuscript Online |
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2015-01-27 15:33 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Observational Study |
| Article Title |
Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shigenori Kadowaki, Miho Kakuta, Shuhei Takahashi, Akemi Takahashi, Yoshiko Arai, Yoji Nishimura, Toshimasa Yatsuoka, Akira Ooki, Kensei Yamaguchi, Keitaro Matsuo, Kei Muro and Kiwamu Akagi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Japanese Ministry of Health, Labor and Welfare |
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| Corresponding Author |
Kiwamu Akagi, MD, PhD, Division of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center, 818 Komuro, Ina-machi, Kitaadachi-gun, Saitama 362-0806, Japan. akagi@cancer-c.pref.saitama.jp |
| Key Words |
Colorectal cancer; KRAS; BRAF; Microsatellite instability; Prognostic factor |
| Core Tip |
Although KRAS and BRAF mutations play a critical role in colorectal cancer development, little is known regarding the prognostic role of these genetic alterations after adjustment for microsatellite instability status in Asian populations. To the authors’ knowledge, the current study is the first large-scale study to clarify the impact of KRAS and BRAF mutations on the survival outcomes of colorectal cancer in Asian populations. We found that KRAS and BRAF mutations were separately associated with inferior disease-free survival and overall survival, independent of microsatellite instability status, in patients with curatively resected colorectal cancer. |
| Publish Date |
2015-01-27 15:33 |
| Citation |
Kadowaki S, Kakuta M, Takahashi S, Takahashi A, Arai Y, Nishimura Y, Yatsuoka T, Ooki A, Yamaguchi K, Matsuo K, Muro K, Akagi K. Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer. World J Gastroenterol 2015; 21(4): 1275-1283 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i4/1275.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i4.1275 |
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