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1/27/2015 3:33:00 PM | Browse: 567 | Download: 680
Publication Name World Journal of Gastroenterology
Manuscript ID 12053
Country/Territory Japan
Received
2014-06-19 20:19
Peer-Review Started
2014-06-20 20:21
To Make the First Decision
2014-07-21 13:31
Return for Revision
2014-07-28 15:05
Revised
2014-09-09 00:00
Second Decision
2014-10-15 07:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-10-15 08:10
Articles in Press
2014-10-15 08:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-01-14 14:21
Publish the Manuscript Online
2015-01-27 15:33
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Observational Study
Article Title Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer
Manuscript Source Unsolicited Manuscript
All Author List Shigenori Kadowaki, Miho Kakuta, Shuhei Takahashi, Akemi Takahashi, Yoshiko Arai, Yoji Nishimura, Toshimasa Yatsuoka, Akira Ooki, Kensei Yamaguchi, Keitaro Matsuo, Kei Muro and Kiwamu Akagi
Funding Agency and Grant Number
Funding Agency Grant Number
Japanese Ministry of Health, Labor and Welfare
Corresponding author Kiwamu Akagi, MD, PhD, Division of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center, 818 Komuro, Ina-machi, Kitaadachi-gun, Saitama 362-0806, Japan. akagi@cancer-c.pref.saitama.jp
Keywords Colorectal cancer; KRAS; BRAF; Microsatellite instability; Prognostic factor
Core Tip Although KRAS and BRAF mutations play a critical role in colorectal cancer development, little is known regarding the prognostic role of these genetic alterations after adjustment for microsatellite instability status in Asian populations. To the authors’ knowledge, the current study is the first large-scale study to clarify the impact of KRAS and BRAF mutations on the survival outcomes of colorectal cancer in Asian populations. We found that KRAS and BRAF mutations were separately associated with inferior disease-free survival and overall survival, independent of microsatellite instability status, in patients with curatively resected colorectal cancer.
Publish Date 2015-01-27 15:33
Citation Kadowaki S, Kakuta M, Takahashi S, Takahashi A, Arai Y, Nishimura Y, Yatsuoka T, Ooki A, Yamaguchi K, Matsuo K, Muro K, Akagi K. Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer. World J Gastroenterol 2015; 21(4): 1275-1283
Url http://www.wjgnet.com/1007-9327/full/v21/i4/1275.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i4.1275
Full Article (PDF) WJG-21-1275.pdf
Full Article (Word) WJG-21-1275.doc
Manuscript File 12053-Review.docx
Answering Reviewers 12053-Answering reviewers.pdf
Copyright License Agreement 12053-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 12053-Language certificate.pdf
Peer-review Report 12053-Peer review(s).pdf
Scientific Misconduct Check 12053-CrossCheck.jpg
Scientific Editor Work List 12053-Scientific editor work list.pdf