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9/20/2026 3:29:00 AM | Browse: 0 | Download: 0
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Received |
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2026-03-01 09:14 |
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Peer-Review Started |
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2026-03-01 09:19 |
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First Decision by Editorial Office Director |
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2026-03-27 10:47 |
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Return for Revision |
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2026-03-27 10:47 |
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Revised |
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2026-04-09 14:20 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-06-04 02:54 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-04 03:48 |
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Articles in Press |
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2026-06-04 03:48 |
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Edit the Manuscript by Language Editor |
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2026-06-10 16:36 |
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Typeset the Manuscript |
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2026-08-29 06:34 |
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Publish the Manuscript Online |
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2026-09-20 03:29 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Review |
| Article Title |
Osteoprotegerin and receptor activator of NF-kappaB ligand as biomarkers for bone resorption-related disorders
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tapesh Lalotra, Arunagiri Gunasekar, Naveen Jeyaraman, Arulkumar Nallakumarasamy, Sathish Muthu, Viji Devanand and Madhan Jeyaraman |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Madhan Jeyaraman, MD, PhD, Researcher, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com |
| Key Words |
Receptor activator of NF-kappaB; Receptor activator of NF-kappaB/receptor activator of NF-kappaB ligand; Osteoprotegerin axis; Osteoclast; Osteoporosis |
| Core Tip |
The receptor activator of NF-kappaB/receptor activator of NF-kappaB ligand (RANKL)/osteoprotegerin (OPG) pathway is a pivotal bone remodelling pathway and its disruption is responsible for the osteoclast-driven bone resorption in the disease states of osteoporosis, arthritis and bone-related cancer. Plasma RANKL and OPG, and their ratio, may be more sensitive indicators for diagnosis, fracture prediction and therapy assessment. While assays are variable, there is evidence that the RANKL/OPG ratio could be a better predictor than either marker alone - and has the potential to improve diagnosis, treatment and outcomes in bone resorption disease. |
| Publish Date |
2026-09-20 03:29 |
| Citation |
Lalotra T, Gunasekar A, Jeyaraman N, Nallakumarasamy A, Muthu S, Devanand V, Jeyaraman M. Osteoprotegerin and receptor activator of NF-kappaB ligand as biomarkers for bone resorption-related disorders. World J Exp Med 2026; 16(3): 120531
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| URL |
https://www.wjgnet.com/2220-315x/full/v16/i3/120531.htm |
| DOI |
https://doi.org/10.5493/wjem.120531 |
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