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9/14/2026 6:00:11 AM | Browse: 1 | Download: 0
Publication Name World Journal of Gastroenterology
Manuscript ID 120563
Country China
Received
2026-03-03 03:07
Peer-Review Started
2026-03-03 03:07
First Decision by Editorial Office Director
2026-04-13 09:32
Return for Revision
2026-04-13 09:32
Revised
2026-05-02 07:37
Publication Fee Transferred
2026-05-09 15:38
Second Decision by Editor
2026-08-26 02:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-08-26 08:34
Articles in Press
2026-08-26 08:34
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-09-09 00:38
Publish the Manuscript Online
2026-09-14 06:00
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Systematic Reviews
Article Title Clinical efficacy of pharmacological and non-pharmacological interventions for constipation-predominant irritable bowel syndrome
Manuscript Source Unsolicited Manuscript
All Author List Chen Li, Ji-Wu Yang, Si-Yuan Zhang, Wei Cheng, Hong-Bo Shi, Hai-Bin Shi and Chuan Li
ORCID
Author(s) ORCID Number
Chen Li http://orcid.org/0009-0001-0671-5416
Ji-Wu Yang http://orcid.org/0000-0001-7626-3163
Funding Agency and Grant Number
Funding Agency Grant Number
Yunnan Provincial Department of Education Scientific Research Fund Project No. 2023Y0996
Corresponding Author Ji-Wu Yang, Professor, Department of General Surgery II, The First Affiliated Hospital of Dali University, No. 32 Carlsberg Avenue, Dali Bai Autonomous Prefecture, Dali 671000, Yunnan Province, China. yangjiwu64@126.com
Key Words Constipation-predominant irritable bowel syndrome; Pharmacological treatment; Non-pharmacological treatment; Clinical efficacy; Network meta-analysis; Systematic review
Core Tip A comprehensive review and network meta-analysis has been conducted to determine the effectiveness of pharmacological and non-pharmacological therapies for constipation dominant irritable bowel syndrome. The assessment considered 14 different interventions depending on the important outcomes like frequency of bowel movements, consistency of stool, severity of symptoms, quality of life and adverse effects. According to the research, transcutaneous auricular vagus nerve stimulation, tenapanor, acupuncture, and probiotics are quite effective. These findings suggest the need for more personalized treatment approaches, and the need for further high-quality trials to confirm.
Publish Date 2026-09-14 06:00
Citation

Li C, Yang JW, Zhang SY, Cheng W, Shi HB, Shi HB, Li C. Clinical efficacy of pharmacological and non-pharmacological interventions for constipation-predominant irritable bowel syndrome. World J Gastroenterol 2026; 32(40): 120563

URL https://www.wjgnet.com/1007-9327/full/v32/i40/120563.htm
DOI https://doi.org/10.3748/wjg.120563
Full Article (PDF) WJG-32-120563-with-cover.pdf
PRISMA 2009 Checklist 120563-PRISMA-2009-Checklist.pdf
Manuscript File 120563_Auto_Edited_012141.docx
Answering Reviewers 120563-answering-reviewers.pdf
Audio Core Tip 120563-audio.mp3
Biostatistics Review Certificate 120563-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 120563-conflict-of-interest-statement.pdf
Copyright License Agreement 120563-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 120563-non-native-speakers.pdf
Peer-review Report 120563-peer-reviews.pdf
Scientific Misconduct Check 120563-scientific-misconduct-check.png
CrossCheck Report 120563-crosscheck-report.pdf