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Articles Published Processes
7/24/2026 10:16:20 AM | Browse: 2 | Download: 0
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Received |
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2026-03-03 02:31 |
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Peer-Review Started |
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2026-03-03 02:34 |
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First Decision by Editorial Office Director |
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2026-03-26 10:14 |
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Return for Revision |
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2026-03-26 10:14 |
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Revised |
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2026-04-03 17:15 |
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Publication Fee Transferred |
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2026-04-09 06:51 |
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Second Decision by Editor |
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2026-05-29 03:08 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-05 08:37 |
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Articles in Press |
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2026-06-05 08:37 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-21 01:02 |
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Publish the Manuscript Online |
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2026-07-24 10:16 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Clinical Neurology |
| Manuscript Type |
Basic Study |
| Article Title |
Integrated patient induced pluripotent stem cell models and GAA-/- mice reveal central nervous system neural pathology in infantile-onset Pompe disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Chang Jiao, Dan-Dan Zhao, Hai-Yan Zhang and Fu-Chen Liu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Shandong Province |
ZR2023MH180 |
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| Corresponding Author |
Fu-Chen Liu, MD, PhD, Professor, Department of Neurology, Qilu Hospital of Shandong University, No. 107 West Wenhua Road, Jinan 250012, Shandong Province, China. fuchen.liu@email.sdu.edu.cn |
| Key Words |
Pompe disease; Lysosomal storage disease; Central nervous system; Blood-brain barrier; Induced pluripotent stem cells |
| Core Tip |
This study integrates patient-derived induced pluripotent stem cell neural lineages and GAA-/- mice to model central nervous system pathology in infantile-onset Pompe disease. Patient-specific cortical neurons, astrocytes, oligodendrocytes, and motor neurons recapitulate key lysosomal pathology seen in vivo. GAA-/- mice exhibit progressive glycogen accumulation, astrogliosis, and neuronal loss. This dual-platform approach faithfully reproduces infantile-onset Pompe disease neural features, providing a valuable system for mechanistic research and testing central nervous system-directed therapies. |
| Publish Date |
2026-07-24 10:16 |
| Citation |
Jiao YC, Zhao DD, Zhang HY, Liu FC. Integrated patient induced pluripotent stem cell models and GAA-/- mice reveal central nervous system neural pathology in infantile-onset Pompe disease. World J Stem Cells 2026; 18(7): 120578
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i7/120578.htm |
| DOI |
https://doi.org/10.4252/wjsc.120578 |
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