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6/26/2026 9:50:20 AM | Browse: 0 | Download: 0
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Received |
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2026-03-03 03:32 |
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Peer-Review Started |
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2026-03-03 03:33 |
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First Decision by Editorial Office Director |
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2026-03-17 10:42 |
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Return for Revision |
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2026-03-17 11:36 |
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Revised |
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2026-04-04 04:37 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-15 02:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-15 06:03 |
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Articles in Press |
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2026-05-15 06:03 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-12 13:56 |
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Publish the Manuscript Online |
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2026-06-26 09:50 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Opinion Review |
| Article Title |
LGALS3 signaling and macrophage ferroptosis in steatohepatitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Wei Liu and Zhuo-Jin Shi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zhuo-Jin Shi, DDS, School/Hospital of Stomatology, Zhejiang Chinese Medical University, No.548 Binwen Road, Hangzhou 310053, Zhejiang Province, China. szj@zcmu.edu.cn |
| Key Words |
Metabolic dysfunction-associated steatohepatitis; LGALS3; Ferroptosis; GPX4; Macrophage; Traditional Chinese medicine; Botanical drug development; Fibrosis |
| Core Tip |
Macrophage-linked ferroptosis has emerged as a plausible injury-amplifying layer in steatohepatitis. A recent study of Qiweizhigan granule proposes an LGALS3-TRAF6-GPX4 framework connecting inflammatory activation to ferroptotic vulnerability. Its main value lies in generating a testable translational model rather than a settled mechanism. Future progress will depend on cell-specific causality, human-relevant validation, mechanism-linked potency assays, and clinically deployable biomarker strategies. |
| Publish Date |
2026-06-26 09:50 |
| Citation |
Liu W, Shi ZJ. LGALS3 signaling and macrophage ferroptosis in steatohepatitis. World J Hepatol 2026; 18(6): 120591
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| URL |
https://www.wjgnet.com/1948-5182/full/v18/i6/120591.htm |
| DOI |
https://doi.org/10.4254/wjh.120591 |
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