| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Intracystic glucose is superior to CEA in diagnosing mucinous pancreatic cysts in genomic era: systematic review and meta-analysis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Giacomo Emanuele Maria Rizzo, Giuseppe Infantino, Giovanni Marchegiani, Jorge D Machicado, Marco Del Chiaro, Ilaria Tarantino, Gemma Rossi, Paolo Giorgio Arcidiacono, Giuseppe Vanella, Lucia Guilabert, Sara Nikolić and Gabriele Capurso |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Giacomo Emanuele Maria Rizzo, MD, PhD, Gastroenterology and Endoscopy Unit, Department of Diagnostic and Therapeutic Services, IRCCS-ISMETT, UPMC Italy, Via Tricomi, 5, Palermo 90127, Sicilia, Italy. g.rizzo.gr@gmail.com |
| Key Words |
Pancreas; Pancreatic cyst; Mucinous cyst; Intracystic glucose; Intracystic carcinoembryonic antigen; Genetic test |
| Core Tip |
Accurate diagnosis of pancreatic cysts is fundamental for patient management. Intracystic glucose, a simple and cost-effective marker, showed promising results compared to carcinoembryonic antigen(CEA) and emerging molecular markers. Nonetheless, low quality evidences and weak recommendation have been reported in the guidelines. In this study, sixteen studies showed glucose had higher accuracy (Odd Ratio [OR] 3.35) and sensitivity(OR 9.36) than CEA, while CEA had greater specificity(OR 0.43). These findings support the use of intracystic glucose as a methodologically stable biomarker, particularly suitable as a rule-out test for mucinous cysts. Therefore, this study reinforces the role of intracystic glucose as a first-line diagnostic biomarker in identifying mucinous pancreatic cysts. Physicians can easily use intracystic glucose in identifying mucinous cysts with greater certainty. |
| Publish Date |
2026-05-20 08:53 |
| Citation |
Rizzo GEM, Infantino G, Marchegiani G, Machicado JD, Del Chiaro M, Tarantino I, Rossi G, Arcidiacono PG, Vanella G, Guilabert L, Nikolić S, Capurso G. Intracystic glucose is superior to CEA in diagnosing mucinous pancreatic cysts in genomic era: systematic review and meta-analysis. World J Clin Oncol 2026; 17(5): 120600 |
| URL |
https://www.wjgnet.com/2218-4333/full/v17/i5/120600.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v17.i5.120600 |
