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Articles Published Processes
9/10/2026 12:49:03 AM | Browse: 2 | Download: 0
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Received |
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2026-03-03 03:14 |
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Peer-Review Started |
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2026-03-03 03:15 |
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First Decision by Editorial Office Director |
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2026-04-17 08:11 |
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Return for Revision |
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2026-04-17 08:11 |
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Revised |
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2026-04-20 17:15 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-25 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-25 07:48 |
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Articles in Press |
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2026-05-25 07:48 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-09 09:34 |
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Publish the Manuscript Online |
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2026-09-10 00:49 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Editorial |
| Article Title |
Imaging tumor heterogeneity to predict response to transarterial chemoembolization in hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Arunkumar Krishnan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Arunkumar Krishnan, MD, Department of Supportive Oncology, Atrium Health Levine Cancer, Atrium Health Wake Forest Baptist Comprehensive Cancer Center, 1021 Morehead Medical Dr, Charlotte, NC 28204, United States. dr.arunkumar.krishnan@gmail.com |
| Key Words |
Hepatocellular carcinoma; Transarterial chemoembolization; Intratumoral heterogeneity; Habitat imaging; Magnetic resonance imaging; Radiomics; Predictive modeling; Personalized medicine |
| Core Tip |
The study by Lv et al integrated contrast-enhanced magnetic resonance imaging-derived habitat features, conventional radiomics, and clinical variables to predict early response to transarterial chemoembolization in hepatocellular carcinoma, achieving area under the curve values of 0.97 and 0.93 in the training and validation cohorts, respectively. While the ecological diversity index and multicenter design are meaningful advancements, several key methodological issues remain unresolved: Feature selection outside nested cross-validation, which risks data leakage and overly optimistic performance estimates; confounding from mixed protocols; outcome misclassification due to the use of both computed tomography and magnetic resonance imaging follow-up; and insufficient inter-site harmonization. Prospective validation, integration of multi-sequence imaging, and studies analyzing the impact on decision-making are necessary before implementing this in clinical practice. |
| Publish Date |
2026-09-10 00:49 |
| Citation |
Krishnan A. Imaging tumor heterogeneity to predict response to transarterial chemoembolization in hepatocellular carcinoma. World J Gastroenterol 2026; 32(39): 120606
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i39/120606.htm |
| DOI |
https://doi.org/10.3748/wjg.120606 |
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