| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Association of severe thrombocytopenia with prognosis following transjugular intrahepatic portosystemic shunt in cirrhotic patients with portal hypertension
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Liu Zhang, Shi-Qi Xu, Yi-Jiang Zhu, Li Dong, Liang Yin, Jin-Chang Xiao, De-Lei Cheng, Rui-Feng Wang and Chun-Ze Zhou |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82370748 |
| Scientific Research Foundation of the Education Department of Anhui Province |
No. 2022AH040189 |
| Anhui Provincial Health Commission Scientific Research Project |
No. AHWJ2024Aa10141 |
|
| Corresponding Author |
Chun-Ze Zhou, Assistant Professor, MD, School of Graduate, Bengbu Medical University, No. 2600 Donghai Avenue, Bengbu 233030, Anhui Province, China. zhouchunze@ustc.edu.cn |
| Key Words |
Thrombocytopenia; Transjugular intrahepatic portosystemic shunt; Portal hypertension; Liver cirrhosis; Prognosis |
| Core Tip |
In this multicenter study of 434 cirrhotic patients, severe thrombocytopenia (< 50 × 109/L) was initially associated with poorer survival after transjugular intrahepatic portosystemic shunt (TIPS), but this association vanished after adjusting for liver disease severity using propensity score matching. Although severe thrombocytopenia correlated with an increased risk of minor bleeding, it was not linked to moderate-to-severe or procedural hemorrhage. These findings challenge conventional assumptions by demonstrating that baseline liver dysfunction, not platelet count, is the key driver of post-TIPS prognosis. Clinicians should therefore focus on comprehensive liver function evaluation rather than platelet thresholds when assessing TIPS candidates. |
| Publish Date |
2026-07-27 09:36 |
| Citation |
Zhang L, Xu SQ, Zhu YJ, Dong L, Yin L, Xiao JC, Cheng DL, Wang RF, Zhou CZ. Association of severe thrombocytopenia with prognosis following transjugular intrahepatic portosystemic shunt in cirrhotic patients with portal hypertension. World J Gastrointest Surg 2026; 18(7): 120610
|
| URL |
https://www.wjgnet.com/1948-9366/full/v18/i7/120610.htm |
| DOI |
https://doi.org/10.4240/wjgs.v18.i7.120610 |
