| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Case Control Study |
| Article Title |
Association of gene variants with susceptibility to type 2 diabetes among Omanis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sawsan Al-Sinani, Nicolas Woodhouse, Ali Al-Mamari, Omaima Al-Shafie, Mohammed Al-Shafaee, Said Al-Yahyaee, Mohammed Hassan, Deepali Jaju, Khamis Al-Hashmi, Mohammed Al-Abri, Khalid Al-Rassadi, Syed Rizvi, Yengo Loic, Philippe Froguel and Riad Bayoumi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Research Council (TRC), Muscat, Oman |
RC/MED/BIOC/10/01 |
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| Corresponding Author |
Sawsan Al-Sinani, PhD Biochemistry, Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box-35, Muscat 123,
Sultanate of Oman. sawsan.alsinani@gmail.com
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| Key Words |
Type 2 diabetes; Genetics; Oman; Case-control; Association; Gene; Variants |
| Core Tip |
To investigate the association of 10 known common gene variants with susceptibility to type 2 diabetes mellitus (T2D) among Omani Arabs using case-control design. A total of 992 diabetic patients and 294 normoglycemic Omani Arabs were genotyped for the following gene variants: KCNJ11 (rs5219), TCF7L2 (rs7903146), CDKAL1 (rs10946398), CDKN2A/B (rs10811661), FTO (rs9939609 and rs8050136), IGF2BP2 (rs4402960), SLC30A8 (rs13266634) CAPN10 (rs3792267) and HHEX (rs1111875). Four gene variants showed significant association with T2D risk: KCNJ11 (rs5219), TCF7L2 (rs7903146), CDKAL1 (rs10946398) and CDKN2A/B (rs10811661). The highest genotype variation % between diabetics and controls was found at KCNJ11 and TCF7L2 gene variants.
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| Publish Date |
2015-03-19 18:00 |
| Citation |
Al-Sinani S, Woodhouse N, Al-Mamari A, Al-Shafie O, Al-Shafaee M, Al-Yahyaee S, Hassan M, Jaju D, Al-Hashmi K, Al-Abri M, Al-Rassadi K, Rizvi S, Loic Y, Froguel P, Bayoumi R. Association of gene variants with susceptibility to type 2 diabetes among Omanis. World J Diabetes 2015; 6(2): 358-366 |
| URL |
http://www.wjgnet.com/1948-9358/full/v6/i2/358.htm |
| DOI |
http://dx.doi.org/10.4239/wjd.v6.i2.358 |
