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Articles Published Processes
10/15/2026 5:45:56 AM | Browse: 1 | Download: 2
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Received |
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2026-03-06 02:18 |
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Peer-Review Started |
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2026-03-06 02:18 |
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First Decision by Editorial Office Director |
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2026-04-03 09:10 |
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Return for Revision |
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2026-04-03 09:10 |
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Revised |
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2026-04-07 01:39 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-15 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-15 07:41 |
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Articles in Press |
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2026-05-15 07:41 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-10-07 12:03 |
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Publish the Manuscript Online |
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2026-10-15 05:45 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Long-term lymphoma risk in thiopurine-treated inflammatory bowel disease: A 15-year propensity-matched cohort study
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Manjeet K Goyal, Rishi Chowdhary, Megh Patel, Marc Landsman, Kirti Arora, Shivam Kalra, Rahul Chowdhary, Ashita R Vuthaluru, Sowmya Durga Subhasri Guna and Vishal Sharma |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Manjeet K Goyal, Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, Ansari Nagar East, New Delhi 110029, India. manjeetgoyal@gmail.com |
| Key Words |
Inflammatory bowel diseases; Thiopurine; Lymphoma; Immunosuppressive agents; Risk assessment; Advanced therapy; Drug-related side effects and adverse reactions |
| Core Tip |
Thiopurines remain central to maintenance therapy in inflammatory bowel disease (IBD), yet concerns about lymphoma risk complicate long-term use. This large, propensity-matched cohort study clarifies the temporal dynamics of malignancy risk, using 5-aminosalicylates as a safe active comparator. We demonstrate that thiopurines are not associated with increased lymphoma risk during the first three years of therapy, with risk elevation emerging only after prolonged use. These findings support a time-dependent, immune suppression-linked oncogenic mechanism and provide a rational basis for limited-duration thiopurine therapy with individualized risk stratification to maximize safety in IBD care. |
| Publish Date |
2026-10-15 05:45 |
| Citation |
Goyal MK, Chowdhary R, Patel M, Landsman M, Arora K, Kalra S, Chowdhary R, Vuthaluru AR, Subhasri Guna SD, Sharma V. Long-term lymphoma risk in thiopurine-treated inflammatory bowel disease: A 15-year propensity-matched cohort study. World J Gastroenterol 2026; 32(45): 120646
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i45/120646.htm |
| DOI |
https://doi.org/10.3748/wjg.120646 |
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