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6/3/2026 7:29:03 AM | Browse: 0 | Download: 0
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Received |
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2026-03-06 02:15 |
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Peer-Review Started |
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2026-03-06 02:15 |
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First Decision by Editorial Office Director |
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2026-03-27 10:20 |
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Return for Revision |
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2026-03-27 10:20 |
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Revised |
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2026-04-09 09:21 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-11 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-11 06:16 |
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Articles in Press |
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2026-05-11 06:16 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-26 08:28 |
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Publish the Manuscript Online |
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2026-06-03 07:29 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Clinical Neurology |
| Manuscript Type |
Editorial |
| Article Title |
Esmolol in acute ischemic stroke thrombolysis: Benefits confined to atrial fibrillation and hypertensive patients
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Hafiz M Ahmed and Umm E Aimen |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hafiz M Ahmed, MD, Department of Medicine, Punjab Medical College, Faisalabad Medical University, Sarogdha Road, Faisalabad 38000, Pakistan. mohammadahmed818@yahoo.com |
| Key Words |
Esmolol; Acute ischemic stroke; Intravenous thrombolysis; Blood pressure management; Atrial fibrillation; Hypertension; Cerebral perfusion; Beta-blocker |
| Core Tip |
Esmolol, an ultrashort-acting beta-1 selective blocker, is increasingly used for pre-thrombolysis blood pressure control in acute ischemic stroke, but evidence for its safety in this setting is limited. In a study of 149 patients with acute ischemic stroke undergoing intravenous thrombolysis, Papamichalis et al report that esmolol-treated patients showed significantly worse 3-month functional outcomes, defined by modified Rankin Scale score > 2, compared with untreated patients. Subgroup analyses revealed that this harm was confined to patients without atrial fibrillation and those without a history of hypertension, while outcomes were not significantly different in patients with atrial fibrillation or established hypertension. These data support individualized antihypertensive selection and underscore the need for prospective trials in this underexplored but clinically critical area. |
| Publish Date |
2026-06-03 07:29 |
| Citation |
Ahmed HM, Aimen UE. Esmolol in acute ischemic stroke thrombolysis: Benefits confined to atrial fibrillation and hypertensive patients. World J Clin Cases 2026; 14(17): 120665
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| URL |
https://www.wjgnet.com/2307-8960/full/v14/i17/120665.htm |
| DOI |
https://doi.org/10.12998/wjcc.v14.i17.120665 |
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