Publication Name	World Journal of Gastroenterology
Manuscript ID	1207
Country	Finland

Received	2012-11-20 18:58
Peer-Review Started	2012-12-24 10:39
To Make the First Decision	2013-01-06 15:01
Return for Revision	2013-01-06 15:44
Revised	2013-01-22 19:42
Second Decision	2013-04-18 16:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-04-19 06:18
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-05-10 17:06
Typeset the Manuscript	2013-05-24 11:06
Publish the Manuscript Online	2013-06-04 12:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Low trypsinogen-1 expression in pediatric ulcerative colitis patients who undergo surgery
Manuscript Source	Invited Manuscript
All Author List	Maija Piekkala, Jaana Hagström, Maarit Tanskanen, Risto Rintala, Caj Haglund and Kaija-Leena Kolho
Funding Agency and Grant Number	Funding Agency Grant Number Päivikki and Sakari Sohlberg Foundation to Piekkala M Helsinki University Central Hospital Grant to Kolho KL Finnish Pediatric Research Foundation to Kolho KL
Corresponding Author	Maija Piekkala, BMed, Children's Hospital, University of Helsinki, PO Box 281, FIN-00029 HUS, Helsinki, Finland. maija.piekkala@helsinki.fi
Key Words	Children; Ulcerative colitis; Inflammatory bowel disease; Matrix metalloproteinase-9 resection; Trypsin inhibitor
Core Tip	The risk factors for aggressive pediatric ulcerative colitis (UC) were studied in 24 patients who had undergone surgery by staining diagnostic tissue samples for matrix metalloproteinase-9 and trypsinogen-1 (Tryp-1) and Tryp-2, as well as a trypsin inhibitor. In the UC group, there were significantly more samples that were matrix metalloproteinase-9 positive in comparison to the samples from non-inflammatory bowel disease patients. UC patients undergoing colectomy showed lower immunopositivity of Tryp-1 in the colon epithelium in their diagnostic biopsies when compared to that of conservatively treated patients and non-inflammatory bowel disease patients. The discovery of a low trypsinogen level at diagnosis warrants further study.
Publish Date	2013-06-04 12:34
Citation	Piekkala M, Hagström J, Tanskanen M, Rintala R, Haglund C, Kolho KL. Low trypsinogen-1 expression in pediatric ulcerative colitis patients who undergo surgery. World J Gastroenterol 2013; 19(21): 3272-3280
URL	http://www.wjgnet.com/1007-9327/full/v19/i21/3272.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i21.3272

Full Article (PDF)	WJG-19-3272.pdf
Manuscript File	1207-Review.doc
Answering Reviewers	1207-Answering reviewers.doc
Copyright License Agreement	1207-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	ethics.pdf
Non-Native Speakers of English Editing Certificate	1207-Language cetificate.pdf
Peer-review Report	1207-Peer review.pdf
Scientific Editor Work List	1207-Scientific editor work list.doc