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Articles Published Processes
1/20/2015 9:10:00 PM | Browse: 1109 | Download: 1451
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Received |
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2014-06-20 08:18 |
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Peer-Review Started |
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2014-06-20 21:02 |
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To Make the First Decision |
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2014-08-06 17:23 |
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Return for Revision |
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2014-08-08 13:50 |
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Revised |
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2014-08-16 05:16 |
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Second Decision |
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2014-09-29 17:08 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-09-29 17:10 |
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Articles in Press |
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2014-09-30 10:52 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-01-09 15:28 |
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Publish the Manuscript Online |
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2015-01-20 20:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Physiology |
| Manuscript Type |
Autobiography |
| Article Title |
Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sabrina L McIlwrath and Karin N Westlund |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health |
NINDS R01 NS39041 |
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| Corresponding Author |
Karin N Westlund, PhD, Professor, Department of Physiology, University of Kentucky, MS-508 Medical Center, 800 Rose St., Lexington, KY 40536-0298, United States. kwhigh2@uky.edu |
| Key Words |
Lieber-DeCarli diet; Orphanin FQ receptor; Metabotropic glutamate receptor; Liver steatosis; Pain; Behavior; Glucose tolerance; Type 3c diabetes mellitus |
| Core Tip |
Chronic pancreatitis is a progressive and potentially fatal disease caused by persistent unresolved inflammation and pancreatic fibrosis. It can be accompanied by intractable abdominal pain and progress to type 3c diabetes mellitus (T3cDM) and pancreatic cancer. Animal models of acute pancreatitis are typically chemically induced, invasive, of short duration, and have a high mortality rate. This study characterizes a diet-induced chronic rat model closely mimicking poor human dietary choices to investigate therapies for alcoholic chronic pancreatitis with developing T3cDM. The efficacy of acute opioid and non-opioid pharmacological interventions are compared to morphine in pain-related behavior tests. |
| Publish Date |
2015-01-20 20:12 |
| Citation |
McIlwrath SL, Westlund KN. Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats. World J Gastroenterol 2015; 21(3): 836-853 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i3/836.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i3.836 |
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