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Articles Published Processes
7/9/2026 6:58:22 AM | Browse: 0 | Download: 0
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Received |
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2026-03-10 00:24 |
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Peer-Review Started |
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2026-03-12 01:50 |
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First Decision by Editorial Office Director |
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2026-04-04 02:15 |
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Return for Revision |
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2026-04-04 02:15 |
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Revised |
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2026-05-10 16:05 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-28 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-28 03:10 |
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Articles in Press |
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2026-05-28 03:10 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-26 11:03 |
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Publish the Manuscript Online |
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2026-07-09 06:58 |
| ISSN |
1948-9358 (online) |
| Open Access |
Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Editorial |
| Article Title |
Targeting the CTRP3-PTEN-PI3K/AKT axis in diabetic wound repair: Implications for keratinocyte resilience
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Hadi Karimkhani |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hadi Karimkhani, Assistant Professor, PhD, Medical Biochemistry, Istanbul Okan University, Medical School, Tepeören Mahallesi Tuzla Kampüsü, Istanbul 34959, Türkiye. drhadi.h@gmail.com |
| Key Words |
CTRP3; Diabetic wound healing; Keratinocytes; PTEN; PI3K/AKT signaling; Angiogenesis |
| Core Tip |
Diabetic wound healing is severely impaired by metabolic dysregulation, chronic inflammation, and defective keratinocyte function. Emerging evidence highlights CTRP3 as a metabolically responsive adipokine with regenerative potential. Recent experimental findings indicate that CTRP3 promotes keratinocyte proliferation, migration, and angiogenic signaling while suppressing PTEN to activate the PI3K/AKT pathway. This editorial discusses how the CTRP3-PTEN-PI3K/AKT axis integrates metabolic signaling with epithelial repair processes and may represent a promising molecular target for improving diabetic wound healing outcomes. |
| Publish Date |
2026-07-09 06:58 |
| Citation |
Karimkhani H. Targeting the CTRP3-PTEN-PI3K/AKT axis in diabetic wound repair: Implications for keratinocyte resilience. World J Diabetes 2026; 17(7): 120721
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| URL |
https://www.wjgnet.com/1948-9358/full/v17/i7/120721.htm |
| DOI |
https://doi.org/10.4239/wjd.120721 |
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