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9/1/2026 4:34:34 AM | Browse: 0 | Download: 0
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Received |
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2026-03-09 06:23 |
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Peer-Review Started |
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2026-03-09 06:27 |
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First Decision by Editorial Office Director |
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2026-04-23 05:07 |
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Return for Revision |
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2026-04-23 05:07 |
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Revised |
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2026-05-15 01:14 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-06-10 02:33 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-10 03:21 |
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Articles in Press |
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2026-06-10 03:21 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-19 04:49 |
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Publish the Manuscript Online |
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2026-09-01 04:34 |
| ISSN |
2150-5349 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Beyond class switching in multi-refractory inflammatory bowel disease: Nine case reports and review of literature
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jonathan Soldera, Maria Antonia Selbach Pertile, Leticia Nodari Carobin, Daniel Jun Funatsu Brambilla and Eduardo Brambilla |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jonathan Soldera, MD, PhD, Department of Tutor, Gastroenterology and Acute Medicine, University of South Wales, Llantwit Road, Pontypridd, Cardiff CF37 1DL, United Kingdom. jonathansoldera@gmail.com |
| Key Words |
Refractory inflammatory bowel disease; Ulcerative colitis; Crohn’s disease; Advanced combination therapy; Janus kinase inhibitors; Vedolizumab; Tofacitinib; Upadacitinib; Guselkumab; Case report |
| Core Tip |
Multi-refractory inflammatory bowel disease often stalls at a “near-working” partial response to an advanced therapy. This case series (n = 9) suggests that, in carefully selected patients, consolidating partial mechanistic control with structured optimization and add-on advanced combination therapy (an oral Janus kinase inhibitor plus a biologic) may convert incomplete response into deep remission and delay surgery. This approach requires phenotype-driven selection, objective reassessment anchored to endoscopic and biochemical endpoints, rigorous infection exclusion, close monitoring, and predefined stopping rules - recognizing that timely colectomy remains appropriate when objective control fails. |
| Publish Date |
2026-09-01 04:34 |
| Citation |
Soldera J, Pertile MAS, Carobin LN, Brambilla DJF, Brambilla E. Beyond class switching in multi-refractory inflammatory bowel disease: Nine case reports and review of literature. World J Gastrointest Pharmacol Ther 2026; 17(3): 120771
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| URL |
https://www.wjgnet.com/2150-5349/full/v17/i3/120771.htm |
| DOI |
https://doi.org/10.4292/wjgpt.120771 |
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