Publication Name	World Journal of Nephrology
Manuscript ID	12082
Country	Switzerland

Received	2014-06-21 13:44
Peer-Review Started	2014-06-22 22:20
To Make the First Decision	2014-07-18 12:37
Return for Revision	2014-07-18 15:40
Revised	2014-07-23 21:13
Second Decision	2014-09-10 13:32
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-09-10 13:56
Articles in Press	2014-09-10 13:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-10-23 17:46
Publish the Manuscript Online	2014-11-07 16:40

ISSN	2220-6124 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Urology & Nephrology
Manuscript Type	Minireviews
Article Title	From crystalluria to kidney stones, some physicochemical aspects of calcium nephrolithiasis
Manuscript Source	Invited Manuscript
All Author List	Johannes M Baumann and Beat Affolter
Funding Agency and Grant Number
Corresponding Author	Johannes M Baumann, MD, Professor, Stone Research Center Viollier, Alpenstrasse 21A, CH-2502 Biel/Bienne, Switzerland. johannes.denise.baumann@bluewin.ch
Key Words	Calcium nephrolithiasis; Crystalluria; Crystal aggregation; Urinary macromolecules; Self aggregation
Core Tip	The state of urinary saturation with respect to Ca salts is governed by pH, Ca and Ox concentration. Growth of calcium oxalate (CaOx) in urine is too slow that single crystals could acquire a size to be trapped in nephron. The aggregation (AGN) of CaOx in urine was lacking or severely delayed due to inhibition of urinary macromolecules (UM’s). Albumin, after temporary adsorption on calcium phosphate, showed self aggregation and promoted AGN of CaOx. Self aggregated UM’s probably overhelm the electrostatic repulsion of crystals coated by negatively charged UM’s. This mechanism may explain the effect of Randall’s plaques.
Publish Date	2014-11-07 16:40
Citation	Baumann JM, Affolter B. From crystalluria to kidney stones, some physicochemical aspects of calcium nephrolithiasis. World J Nephrol 2014; 3(4): 256-267
URL	http://www.wjgnet.com/2220-6124/full/v3/i4/256.htm
DOI	http://dx.doi.org/10.5527/wjn.v3.i4.256

Full Article (PDF)	WJN-3-256.pdf
Full Article (Word)	WJN-3-256.doc
Manuscript File	12082-Review.doc
Answering Reviewers	12082-Answering reviewers.pdf
Copyright License Agreement	12082-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20140620223757.docx
Peer-review Report	12082-Peer review(s).pdf
Scientific Misconduct Check	12082-CrossCheck.jpg
Scientific Editor Work List	12082-Scientific editor work list.pdf