10/9/2026 4:02:32 AM | Browse: 4 | Download: 3
| Publication Name | World Journal of Clinical Pediatrics |
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| Manuscript ID | 120832 |
| Country | Russia |
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| ISSN | 2219-2808 (online) |
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| Open Access | This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright | ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 |
| Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 |
| Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website | http://www.wjgnet.com |
| Category | Pediatrics | ||||||||||||||||||||||||||||||||||||
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| Manuscript Type | Retrospective Cohort Study | ||||||||||||||||||||||||||||||||||||
| Article Title | Does Takayasu arteritis differ between children and adolescents? Insights from a Russian multicenter cohort | ||||||||||||||||||||||||||||||||||||
| Manuscript Source | Invited Manuscript | ||||||||||||||||||||||||||||||||||||
| All Author List | Vera A Podzolkova, Natalia A Geppe, Anastasia A Glazyrina, Sania I Valieva, Ilia S Avrusin, Seda Kh Kurbanova, Svetlana S Vakhlyarskaya, Yulia O Kostina, Valeria T Yudina, Ekaterina A Lagutina, Maria K Osminina, Elena S Zholobova, Nadezhda S Podchernyaeva, Eva P Turginekova, Lyubov S Sorokina, Siuzanna A Davtian and Mikhail M Kostik | ||||||||||||||||||||||||||||||||||||
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| Corresponding Author | Mikhail M Kostik, MD, PhD, Professor, Department of Hospital Pediatry, Saint Petersburg State Pediatric Medical University, Lytovskaya 2, Saint Petersburg 194100, Sankt-Peterburg, Russia. kost-mikhail@yandex.ru | ||||||||||||||||||||||||||||||||||||
| Key Words | Takayasu arteritis; Children; Adolescents; Vasculitis; Age; Surgery; Disease-modifying anti-rheumatic drugs; Biological drugs; Tocilizumab; Russia | ||||||||||||||||||||||||||||||||||||
| Core Tip | In this first Russian multicenter cohort study, childhood-onset Takayasu arteritis (TA) presents with distinct age-specific clinical phenotypes. Younger children (< 10 years) exhibit lower inflammatory activity but paradoxically require more frequent surgical interventions, suggesting a “burnt-out” presentation at diagnosis due to diagnostic delays. Vascular damage progresses in one-third of patients despite normalized laboratory parameters, confirming the dissociation between systemic inflammation and vessel wall injury. Tocilizumab was the predominant biologic choice with favorable outcomes. These findings emphasize that conventional inflammatory markers are insufficient for monitoring disease activity and that age-specific management strategies are essential for improving long-term outcomes in pediatric TA. | ||||||||||||||||||||||||||||||||||||
| Publish Date | 2026-10-09 04:02 | ||||||||||||||||||||||||||||||||||||
| Citation |
Podzolkova VA, Geppe NA, Glazyrina AA, Valieva SI, Avrusin IS, Kurbanova SK, Vakhlyarskaya SS, Kostina YO, Yudina VT, Lagutina EA, Osminina MK, Zholobova ES, Podchernyaeva NS, Turginekova EP, Sorokina LS, Davtian SA, Kostik MM. Does Takayasu arteritis differ between children and adolescents? Insights from a Russian multicenter cohort. World J Clin Pediatr 2026; 15(4): 120832 |
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| URL | https://www.wjgnet.com/2219-2808/full/v15/i4/120832.htm | ||||||||||||||||||||||||||||||||||||
| DOI | https://doi.org/10.5409/wjcp.120832 |
| Full Article (PDF) | WJCP-15-120832-with-cover.pdf |
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| STROBE Statement | 120832-STROBE-statement.pdf |
| Manuscript File | 120832_Auto_Edited_014933.docx |
| Answering Reviewers | 120832-answering-reviewers.pdf |
| Audio Core Tip | 120832-audio.m4a |
| Biostatistics Review Certificate | 120832-biostatistics-statement.pdf |
| Conflict-of-Interest Disclosure Form | 120832-conflict-of-interest-statement.pdf |
| Copyright License Agreement | 120832-copyright-assignment.pdf |
| Signed Informed Consent Form(s) or Document(s) | 120832-informed-consent-statement.pdf |
| Institutional Review Board Approval Form or Document | 120832-institutional-review-board-statement.pdf |
| Non-Native Speakers of English Editing Certificate | 120832-non-native-speakers.pdf |
| Peer-review Report | 120832-peer-reviews.pdf |
| Scientific Misconduct Check | 120832-scientific-misconduct-check.png |
| CrossCheck Report | 120832-crosscheck-report.pdf |