BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
8/25/2026 6:38:35 AM | Browse: 4 | Download: 0
 |
Received |
|
2026-03-11 03:36 |
|
Peer-Review Started |
|
2026-03-11 03:36 |
|
First Decision by Editorial Office Director |
|
2026-03-20 11:42 |
|
Return for Revision |
|
2026-03-20 11:42 |
|
Revised |
|
2026-04-11 00:14 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2026-05-07 03:22 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-05-07 06:24 |
|
Articles in Press |
|
2026-05-07 06:24 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-08-03 07:55 |
|
Publish the Manuscript Online |
|
2026-08-25 06:38 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
N6-methyladenosine RNA methylation in relation to the inflammatory response, immunity and the intestinal microbiota in inflammatory bowel disease
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Lie Zheng and Sheng-Lei Duan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82574996 |
| Shaanxi Province Traditional Chinese Medicine Research and Innovation Talent Plan Project |
No. TZKN-CXRC-16 |
| Project of Shaanxi Administration of Traditional Chinese Medicine |
No. SZY-KJCYC-2025-JC-010 |
| Shaanxi Province Key Research and Development Plan Project-Social Development Field |
No. 2025SF-YBXM-498 |
| The “Nursery Cultivation Plan” project of Shaanxi Provincial Academy of Chinese Medicine and Shaanxi Provincial Hospital of Traditional Chinese Medicine for the year 2025 |
No. 2025-04 |
| The Fifth Batch of Outstanding Clinical Talents in Traditional Chinese Medicine Project of Shaanxi Province, Shaanxi Traditional Chinese Medicine Letter [2025] |
No. 6 |
|
| Corresponding Author |
Sheng-Lei Duan, Department of Gastroenterology, Shaanxi Hospital of Traditional Chinese Medicine, No. 4 Xihuamen, Xi’an 710003, Shaanxi Province, China. 281930369@qq.com |
| Key Words |
N6-methyladenosine; RNA methylation; Immunity; Intestinal microbiota; Inflammatory bowel disease |
| Core Tip |
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine. N6-methyladenosine (m6A) RNA methylation, which is the most abundant messenger RNA modification in mammalian cells, plays an important role in IBD by influencing various processes, such as RNA stability, splicing, translation, and degradation, and participating in the pathogenesis of IBD. The key enzymes involved in m6A methylation (such as methyltransferase-like 3, methyltransferase-like 4 and fat mass and obesity-associated protein) not only regulate changes in inflammation and immunity in IBD but also bidirectionally regulate the intestinal microenvironment. However, the specific mechanism of m6A methylation modification in IBD needs further exploration. Future research should focus on clarifying the molecular network related to m6A methylation and IBD to provide new intervention methods for clinical practice and improve the outcomes of IBD patients. This article reviews the research progress on m6A RNA methylation in IBD, aiming to improve the understanding of IBD pathogenesis at the epigenetic level and provide new directions for exploring treatments targeting m6A-modified related proteins for IBD. |
| Publish Date |
2026-08-25 06:38 |
| Citation |
Zheng L, Duan SL. N6-methyladenosine RNA methylation in relation to the inflammatory response, immunity and the intestinal microbiota in inflammatory bowel disease. World J Gastroenterol 2026; 32(36): 120873
|
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i36/120873.htm |
| DOI |
https://doi.org/10.3748/wjg.120873 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
