BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
9/1/2026 6:22:41 AM | Browse: 1 | Download: 0
 |
Received |
|
2026-03-11 03:02 |
|
Peer-Review Started |
|
2026-03-11 03:03 |
|
First Decision by Editorial Office Director |
|
2026-04-22 10:40 |
|
Return for Revision |
|
2026-04-22 10:40 |
|
Revised |
|
2026-05-03 13:00 |
|
Publication Fee Transferred |
|
2026-05-08 07:48 |
|
Second Decision by Editor |
|
2026-06-23 02:18 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-06-23 05:33 |
|
Articles in Press |
|
2026-06-23 05:33 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-08-21 07:47 |
|
Publish the Manuscript Online |
|
2026-09-01 06:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Portulaca oleracea L.-derived exosome-like nanoparticles ameliorate colitis by modulating gut microbiota and metabolites to reduce endoplasmic reticulum stress
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Yan Liu, Zi-Xuan Liu, Wei-Wei Tan, Wei-Bing Zhang, Dan Qiao, Shuo-Han Chen, Ya-Li Zhang, Lie Zheng, Wen-Song Ge and Yan-Cheng Dai |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81873253 |
| National Natural Science Foundation of China |
82574996 |
| Shanghai Natural Science Foundation |
22ZR1458800 |
| Scientific Research Project Plan of Shanghai Municipal Health Commission |
202240385 |
| Hongkou District Health Committee |
HKZK2020A01 |
| Shaanxi Province Traditional Chinese Medicine Research and Innovation Talent Plan Project |
TZKN-CXRC-16 |
| Project of Shaanxi Administration of Traditional Chinese Medicine |
SZY-KJCYC-2025-JC-010 |
| Shaanxi Province Key Research and Development Plan Project-Social Development Field |
2025SF-YBXM-498 |
|
| Corresponding Author |
Yan-Cheng Dai, PhD, Department of Gastroenterology, Shanghai Traditional Chinese Medicine-Integrated Hospital Shanghai University of Traditional Chinese Medicine, No. 230 Baoding Road, Hongkou District, Shanghai 200082, China. daiyancheng2005@126.com |
| Key Words |
Portulaca oleracea L.-derived exosome-like nanoparticles; Ulcerative colitis; Endoplasmic reticulum stress; Tight junction; PERK-eIF2α-ATF4 signaling pathway; Gut microbiota; Metabolites |
| Core Tip |
The role of Portulaca oleracea L. (P. oleracea L.) in modulating endoplasmic reticulum stress, gut microbiota and metabolites remained unclear. To investigate this, we prepared exosome-like nanoparticles derived from P. oleracea L. and modeled colitis induced by dextran sulfate sodium and microbiota-transplanted mouse. We found that P. oleracea L.-derived exosome-like nanoparticles (PELNs) intervention alleviated colitis through the modulation of the intestinal microbial community and metabolites. PELNs as a novel, food-derived, colon-targeted therapeutic, offering a promising approach for ulcerative colitis treatment. |
| Publish Date |
2026-09-01 06:22 |
| Citation |
Liu XY, Liu ZX, Tan WW, Zhang WB, Qiao D, Chen SH, Zhang YL, Zheng L, Ge WS, Dai YC. Portulaca oleracea L.-derived exosome-like nanoparticles ameliorate colitis by modulating gut microbiota and metabolites to reduce endoplasmic reticulum stress. World J Gastroenterol 2026; 32(37): 120885
|
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i37/120885.htm |
| DOI |
https://doi.org/10.3748/wjg.120885 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
