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9/18/2026 3:45:46 AM | Browse: 1 | Download: 0
Publication Name World Journal of Gastroenterology
Manuscript ID 120899
Country China
Received
2026-03-12 02:22
Peer-Review Started
2026-03-12 02:22
First Decision by Editorial Office Director
2026-04-03 09:15
Return for Revision
2026-04-03 09:15
Revised
2026-04-20 16:43
Publication Fee Transferred
2026-04-21 15:18
Second Decision by Editor
2026-06-03 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-06-03 07:14
Articles in Press
2026-06-03 07:14
Edit the Manuscript by Language Editor
2026-06-09 18:43
Typeset the Manuscript
2026-09-11 01:22
Publish the Manuscript Online
2026-09-18 03:45
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Imaging Science & Photographic Technology
Manuscript Type Retrospective Study
Article Title Endoscopic ultrasound-based deep learning for predicting chemotherapy response in unresectable pancreatic ductal adenocarcinoma
Manuscript Source Unsolicited Manuscript
All Author List Ze-Hua Li, Jun Weng, Yu-Hong Zeng, Shi-Yong Lin, Shuo Li, Kun-Hao Bai and Guo-Liang Xu
ORCID
Author(s) ORCID Number
Ze-Hua Li http://orcid.org/0000-0001-5624-0087
Jun Weng http://orcid.org/0000-0003-0792-1526
Yu-Hong Zeng http://orcid.org/0000-0002-2654-5653
Shi-Yong Lin http://orcid.org/0000-0002-3881-6422
Kun-Hao Bai http://orcid.org/0000-0003-1184-7576
Guo-Liang Xu http://orcid.org/0000-0002-8882-2636
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China (General Program) No. 82403973, No. 82200442, and No. 82373118
Guangdong Basic and Applied Basic Research Foundation No. 2023A1515010828
Science and Technology Program of Guangzhou No. 2025A04J3768
Guangdong Medical Equipment Association Research Fund No. YZXH2025KT07
Hong Kong Scholar, Hong Kong Scholar No. XJWQ2025016
Corresponding Author Guo-Liang Xu, Department of Endoscopy, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, No. 651 Dongfeng East Road, Yuexiu District, Guangzhou 510060, Guangdong Province, China. xugl@sysucc.org.cn
Key Words Pancreatic ductal adenocarcinoma; Endoscopic ultrasound; Convolutional neural network; Deep learning; Chemotherapy response
Core Tip Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, and predicting chemotherapy response remains challenging. This study developed deep learning models based on pre-treatment endoscopic ultrasound images to predict chemotherapy response in PDAC. Four convolutional neural network architectures were evaluated, with ResNeXt50 demonstrating the best performance in the independent test cohort. The model also enabled effective risk stratification for overall survival, outperforming conventional serum biomarker carbohydrate antigen 19-9. These findings suggest that endoscopic ultrasound-based convolutional neural network models may provide a noninvasive tool to support individualized treatment planning in PDAC.
Publish Date 2026-09-18 03:45
Citation

Li ZH, Weng J, Zeng YH, Lin SY, Li S, Bai KH, Xu GL. Endoscopic ultrasound-based deep learning for predicting chemotherapy response in unresectable pancreatic ductal adenocarcinoma. World J Gastroenterol 2026; 32(41): 120899

URL https://www.wjgnet.com/1007-9327/full/v32/i41/120899.htm
DOI https://doi.org/10.3748/wjg.120899
Full Article (PDF) WJG-32-120899-with-cover.pdf
Manuscript File 120899_Auto_Edited_101620.docx
Answering Reviewers 120899-answering-reviewers.pdf
Audio Core Tip 120899-audio.mp3
Biostatistics Review Certificate 120899-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 120899-conflict-of-interest-statement.pdf
Copyright License Agreement 120899-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 120899-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 120899-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 120899-non-native-speakers.pdf
Supplementary Material 120899-supplementary-material.pdf
Peer-review Report 120899-peer-reviews.pdf
Scientific Misconduct Check 120899-scientific-misconduct-check.png
CrossCheck Report 120899-crosscheck-report.pdf