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8/27/2026 8:00:24 AM | Browse: 3 | Download: 0
Publication Name World Journal of Critical Care Medicine
Manuscript ID 120909
Country Croatia
Received
2026-03-11 03:14
Peer-Review Started
2026-03-11 03:15
First Decision by Editorial Office Director
2026-04-13 09:15
Return for Revision
2026-04-13 09:15
Revised
2026-05-04 19:06
Publication Fee Transferred
Second Decision by Editor
2026-05-21 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-05-21 06:57
Articles in Press
2026-05-21 06:57
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-06-11 06:30
Publish the Manuscript Online
2026-08-27 08:00
ISSN 2220-3141(online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Critical Care Medicine
Manuscript Type Case Report
Article Title Acute intermittent porphyria presenting with rhabdomyolysis and polyneuropathy with severe quadriparesis and respiratory failure: A case report
Manuscript Source Invited Manuscript
All Author List Luka Bielen, Ana Vujaklija Brajković, Ozrenka Zlopaša, Nediljko Šućur, Mila Lovrić, Anja Šitum and Penelope Stein
ORCID
Author(s) ORCID Number
Luka Bielen http://orcid.org/0000-0001-5782-4367
Ana Vujaklija Brajković http://orcid.org/0000-0002-9374-429X
Ozrenka Zlopaša http://orcid.org/0000-0001-6387-6737
Nediljko Šućur http://orcid.org/0009-0006-2797-0391
Mila Lovrić http://orcid.org/0000-0002-2086-643X
Anja Šitum http://orcid.org/0009-0002-0372-1551
Penelope Stein http://orcid.org/0000-0002-7052-6070
Funding Agency and Grant Number
Corresponding Author Ana Vujaklija Brajković, Assistant Professor, MD, PhD, Department of Internal Medicine, University Hospital Centre Zagreb, Kišpatićeva 12, Zagreb 10000, Croatia. avujaklija@gmail.com
Key Words Acute intermittent porphyria; Rhabdomyolysis; Polyneuropathy; Hemin; Givosiran; Case report
Core Tip Rhabdomyolysis is a rare but important manifestation of an acute intermittent porphyria (AIP) attack. In this clinical scenario, urine discolouration might erroneously be ascribed to rhabdomyolysis, underlying the need for AIP diagnostic workup in the right clinical context. Our case illustrates that treatment with hemin and givosiran for longer than two years may be needed after a severe AIP attack with rhabdomyolysis and severe quadriparesis. If the period between givosiran administrations is prolonged, the physician must be vigilant for the possibility of a new attack.
Publish Date 2026-08-27 08:00
Citation

Bielen L, Vujaklija Brajković A, Zlopaša O, Šućur N, Lovrić M, Šitum A, Stein P. Acute intermittent porphyria presenting with rhabdomyolysis and polyneuropathy with severe quadriparesis and respiratory failure: A case report. World J Crit Care Med 2026; 15(3): 120909

URL https://www.wjgnet.com/2220-3141/full/v15/i3/120909.htm
DOI https://doi.org/10.5492/wjccm.120909
Full Article (PDF) WJCCM-15-120909-with-cover.pdf
CARE Checklist–2016 120909-CARE-Checklist-2016.pdf
Manuscript File 120909_Auto_Edited_084255.docx
Answering Reviewers 120909-answering-reviewers.pdf
Audio Core Tip 120909-audio.mp4
Conflict-of-Interest Disclosure Form 120909-conflict-of-interest-statement.pdf
Copyright License Agreement 120909-copyright-assignment.pdf
Signed Consent for Treatment Form(s) or Document(s) 120909-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate 120909-non-native-speakers.pdf
Peer-review Report 120909-peer-reviews.pdf
Scientific Misconduct Check 120909-scientific-misconduct-check.png