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6/18/2026 9:51:23 AM | Browse: 0 | Download: 0
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Received |
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2026-03-12 00:36 |
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Peer-Review Started |
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2026-03-12 01:51 |
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First Decision by Editorial Office Director |
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2026-03-27 10:18 |
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Return for Revision |
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2026-03-27 10:18 |
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Revised |
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2026-04-13 17:40 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-06-02 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-02 08:28 |
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Articles in Press |
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2026-06-02 08:28 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-10 03:52 |
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Publish the Manuscript Online |
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2026-06-18 09:51 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Potential role of angiotensin-converting enzyme inhibitors vs beta-blockers in preventing anticancer agents-induced cardiotoxicity: A systematic review and meta-analysis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Rohab Sohail, Ridda Khattak, Haider Hussain Shah, Zaraq Khan, Azeem Khan, Shahryar Chaudhry, Simran Patel, Rohan Patel, Vyom Patel, Madihah Alam, Samar Mehdi and Manjeet Singh |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Rohab Sohail, Department of Internal Medicine, Bayhealth Medical Center, 640 South State Street, Dover, DE 19904, United States. rohabsohail98@gmail.com |
| Key Words |
Cardiotoxicity; Angiotensin converting enzyme inhibitors; Beta blockers; Anthracycline-induced cardiotoxicity; Transtuzumab-induced cardiotoxicity |
| Core Tip |
This meta-analysis compared angiotensin-converting enzyme inhibitors (ACEI) and beta-blockers for the prevention of anti-cancer agents-induced cardiotoxicity. Across randomized controlled trials, both drug classes showed similar effectiveness in preserving left ventricular ejection fraction and preventing overall, early, and late cardiotoxicity. Overall adverse event rates were similar between groups; however, hypotension and dizziness occurred more frequently with ACEI therapy. These findings suggest that ACEI and beta-blockers provide comparable cardioprotective benefit. Choice of therapy should therefore be individualized based on patient characteristics, blood pressure profile, and tolerability. Larger, adequately powered trials with longer follow-up are needed to determine whether meaningful differences between these strategies emerge over time. |
| Publish Date |
2026-06-18 09:51 |
| Citation |
Sohail R, Khattak R, Hussain Shah H, Khan Z, Khan A, Chaudhry S, Patel S, Patel R, Patel V, Alam M, Mehdi S, Singh M. Potential role of angiotensin-converting enzyme inhibitors vs beta-blockers in preventing anticancer agents-induced cardiotoxicity: A systematic review and meta-analysis. World J Cardiol 2026; 18(6): 120930
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| URL |
https://www.wjgnet.com/1949-8462/full/v18/i6/120930.htm |
| DOI |
https://doi.org/10.4330/wjc.120930 |
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