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9/4/2026 5:57:42 AM | Browse: 0 | Download: 0
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Received |
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2026-03-12 00:33 |
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Peer-Review Started |
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2026-03-13 05:33 |
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First Decision by Editorial Office Director |
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2026-04-10 08:09 |
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Return for Revision |
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2026-04-10 08:09 |
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Revised |
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2026-04-23 04:08 |
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Publication Fee Transferred |
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2026-04-24 09:53 |
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Second Decision by Editor |
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2026-06-10 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-17 07:38 |
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Articles in Press |
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2026-06-17 07:38 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-27 00:37 |
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Publish the Manuscript Online |
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2026-09-04 05:57 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Electroacupuncture alleviates diabetic peripheral neuropathy: Regulates mitochondrial biogenesis and redistribution in peripheral nerve fibers
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xuan Wang, Chong-Xi Yuan, Yun Liu, Wei-Feng Li, Meng-Jiang Lu, Tian-Cheng Xu, Zhi Yu and Bin Xu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82405567 |
| National Natural Science Foundation of China |
No. 82074532 |
| National Natural Science Foundation of China |
No. 82374577 |
| National Natural Science Foundation of China |
No. 82305375 |
| National Natural Science Foundation of China |
No. 82305376 |
| National Natural Science Foundation of China |
No. 82505663 |
| Applied Basic Research Program of Yancheng |
No. YCBK2025031 |
| Jiangsu Province Young Scientific and Technological Talents Promotion Plan |
No. JSTJ-2025-890 |
| Suzhou Science and Technology Innovation Project of Applied Basic Research (Medical and Health) |
No. SYW2024163 |
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| Corresponding Author |
Bin Xu, Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, No. 138 Xianlin Road, Nanjing 210023, Jiangsu Province, China. xubin@njucm.edu.cn |
| Key Words |
Acupuncture; Diabetic peripheral neuropathy; Type 2 diabetes; Mitochondria distribution; Mitochondria biogenesis |
| Core Tip |
Current treatments for diabetic peripheral neuropathy (DPN) remain limited, and new therapeutic strategies are needed. This study suggests that electroacupuncture (EA) exerts protective effects in type 2 DPN rats and may be associated with silent information regulator 1 (SIRT1)/peroxisome proliferator-activated receptor-γ coactivator-1α-mediated mitochondrial biogenesis and mitochondrial redistribution, with more prominent changes observed in intraepidermal nerve fibers than in adjacent keratinocytes. Notably, inhibition of SIRT1 weakened the neural benefits of EA while having limited effects on systemic metabolic parameters, suggesting a partial dissociation between neural and metabolic effects. |
| Publish Date |
2026-09-04 05:57 |
| Citation |
Wang X, Yuan CX, Liu Y, Li WF, Lu MJ, Xu TC, Yu Z, Xu B. Electroacupuncture alleviates diabetic peripheral neuropathy: Regulates mitochondrial biogenesis and redistribution in peripheral nerve fibers. World J Diabetes 2026; 17(9): 120935
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| URL |
https://www.wjgnet.com/1948-9358/full/v17/i9/120935.htm |
| DOI |
https://doi.org/10.4239/wjd.120935 |
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