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Articles Published Processes
10/9/2026 8:15:17 AM | Browse: 1 | Download: 0
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Received |
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2026-03-12 02:21 |
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Peer-Review Started |
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2026-03-12 02:22 |
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First Decision by Editorial Office Director |
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2026-04-02 07:29 |
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Return for Revision |
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2026-04-02 07:29 |
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Revised |
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2026-05-18 09:22 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-07-17 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-07-17 06:03 |
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Articles in Press |
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2026-07-17 06:03 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-10 00:49 |
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Publish the Manuscript Online |
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2026-10-09 08:15 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
miR-4770 promotes colorectal cancer progression by targeting PRKAA2 via m6A modification
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bi-Shun Yi and Huan-Bin Lai |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Huan-Bin Lai, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Lishui University, No. 1188 Liyang Street, Yanquan Street, Liandu District, Lishui 323000, Zhejiang Province, China. lhb26030501@163.com |
| Key Words |
Colorectal cancer; miR-4770; N6-methyladenosine methylation; METTL3; PRKAA2; Malignant progression |
| Core Tip |
This study investigated the role of miR-4770 in colorectal cancer (CRC) and its regulation by N6-methyladenosine (m6A) modification. The results showed that miR-4770 and METTL3 were upregulated in CRC tissues and cells, whereas PRKAA2 was downregulated. METTL3 may promote the maturation of pri-miR-4770 through m6A modification, thereby increasing miR-4770 expression. Functionally, miR-4770 enhanced CRC cell viability, migration, and invasion by directly targeting PRKAA2 and modulating the AMPK/mTOR signaling pathway. These findings suggest that the METTL3/miR-4770/PRKAA2 axis may provide a potential mechanistic basis for CRC progression. |
| Publish Date |
2026-10-09 08:15 |
| Citation |
Yi BS, Lai HB. miR-4770 promotes colorectal cancer progression by targeting PRKAA2 via m6A modification. World J Gastrointest Oncol 2026; 18(10): 120941
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i10/120941.htm |
| DOI |
https://doi.org/10.4251/wjgo.120941 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
