| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Cancer therapy-induced intestinal injury: Mechanisms, clinical manifestations, and management strategies
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yang-Long Nan, Tuan-He Sun, Kai-Jie Ren, Tian-Hao Min, Yu-Yi Ma, Xin Xie, Xiao-Yuan Deng, Yuan-Chang Peng, Yuan-Yuan Liu, Shi-Yao Tong, Wei Wang, Cheng-Xue Dang and Hao Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Social Science Fund of China |
23BRK014 |
|
| Corresponding Author |
Hao Zhang, MD, Department of Surgical Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, No. 227 Yanta West Road, Xi’an 710061, Shaanxi Province, China. hao.zhang@mail.xjtu.edu.cn |
| Key Words |
Cancer therapy; Chemotherapy; Radiotherapy; Intestinal injury; Oxidative stress; Gut microbiota; Inflammation |
| Core Tip |
Cancer therapy-induced intestinal injury is a relatively common, multifaceted side effect of chemotherapy, radiotherapy, targeted therapy, immunotherapy and surgical interventions. The underlying mechanisms include oxidative stress, inflammation, apoptosis and dysbiosis of the gut microbiota; all of them contribute to the disruption of epithelial integrity and intestinal function. This minireview synthesizes current mechanistic insights and therapeutic strategies, with a particular emphasis on microbiota modulation, targeted interventions, and emerging regenerative approaches. A comprehensive understanding of these processes is crucial for developing personalized treatments to prevent or mitigate intestinal injury, improve patient quality of life, and optimize cancer therapy outcomes. |
| Publish Date |
2026-09-18 03:45 |
| Citation |
Nan YL, Sun TH, Ren KJ, Min TH, Ma YY, Xie X, Deng XY, Peng YC, Liu YY, Tong SY, Wang W, Dang CX, Zhang H. Cancer therapy-induced intestinal injury: Mechanisms, clinical manifestations, and management strategies. World J Gastroenterol 2026; 32(41): 120954
|
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i41/120954.htm |
| DOI |
https://doi.org/10.3748/wjg.120954 |
