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Publication Name World Journal of Transplantation
Manuscript ID 120969
Country India
Received
2026-03-12 03:44
Peer-Review Started
2026-03-12 03:45
First Decision by Editorial Office Director
2026-04-15 09:15
Return for Revision
2026-04-15 09:15
Revised
2026-05-03 11:37
Publication Fee Transferred
Second Decision by Editor
2026-06-12 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-06-12 03:53
Articles in Press
2026-06-12 03:53
Edit the Manuscript by Language Editor
2026-06-15 22:04
Typeset the Manuscript
2026-07-24 09:48
Publish the Manuscript Online
2026-09-02 06:21
ISSN 2220-3230 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Transplantation
Manuscript Type Retrospective Cohort Study
Article Title Kidney transplant outcomes in patients with complement dysregulation
Manuscript Source Invited Manuscript
All Author List Manish Balwani, Amit Pasari, Pranjal Kashiv, Vishal Ramteke, Priyanka Tolani, Nishtha Manuja, Mohit Kurundwadkar, Shubham Dubey, Twinkle Pawar, Sunny Malde, Sushrut Gupta, Kapil Sejpal, Vijay Jeyachandran and Vivek B Kute
ORCID
Author(s) ORCID Number
Manish Balwani http://orcid.org/0000-0003-3923-6953
Amit Pasari http://orcid.org/0000-0002-2182-0898
Pranjal Kashiv http://orcid.org/0000-0002-4551-2574
Vishal Ramteke http://orcid.org/0000-0001-6039-728X
Mohit Kurundwadkar http://orcid.org/0009-0008-0428-9012
Shubham Dubey http://orcid.org/0000-0002-9623-7605
Twinkle Pawar http://orcid.org/0000-0002-2665-7647
Sunny Malde http://orcid.org/0009-0007-6389-2789
Sushrut Gupta http://orcid.org/0000-0002-3276-676X
Kapil Sejpal http://orcid.org/0009-0001-6759-5470
Vijay Jeyachandran http://orcid.org/0009-0005-3404-1200
Vivek B Kute http://orcid.org/0000-0002-0002-2854
Funding Agency and Grant Number
Corresponding Author Manish Balwani, Department of Nephrology, Saraswati Kidney Care Center, Near Jai Prakash Metro Station, Nagpur 440015, Mahārāshtra, India. balwani.manish@yahoo.com
Key Words Atypical hemolytic uremic syndrome; Thrombotic microangiopathy; Kidney transplantation; Complement dysregulation; Anti-factor H antibody; CFHR1-CFHR3
Core Tip Complement dysregulation is an important but underrecognized determinant of post-transplant thrombotic microangiopathy. In this retrospective cohort of 38 kidney transplant recipients with complement dysregulation, CFHR1-CFHR3 structural variants predominated, anti-factor H antibodies were frequent, and recurrence occurred in 18.4%. All recurrences developed within the first 1-3 weeks post-transplant and were confined to recipients with complement genetic abnormalities. All episodes were successfully controlled with individualized therapy. Overall patient survival was 94.7%. These findings support systematic complement evaluation, biologic risk stratification, and early targeted intervention to optimize transplant selection, reduce recurrence risk, and improve post-transplant graft outcomes in complement-mediated kidney disease.
Publish Date 2026-09-02 06:21
Citation

Balwani M, Pasari A, Kashiv P, Ramteke V, Tolani P, Manuja N, Kurundwadkar M, Dubey S, Pawar T, Malde S, Gupta S, Sejpal K, Jeyachandran V, Kute VB. Kidney transplant outcomes in patients with complement dysregulation. World J Transplant 2026; 16(3): 120969
URL https://www.wjgnet.com/2220-3230/full/v16/i3/120969.htm
DOI https://doi.org/10.5500/wjt.120969
Full Article (PDF) WJT-16-120969-with-cover.pdf
STROBE Statement 120969-STROBE-statement.pdf
Manuscript File 120969_Auto_Edited_032822.docx
Answering Reviewers 120969-answering-reviewers.pdf
Audio Core Tip 120969-audio.mp3
Biostatistics Review Certificate 120969-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 120969-conflict-of-interest-statement.pdf
Copyright License Agreement 120969-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 120969-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 120969-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 120969-non-native-speakers.pdf
Peer-review Report 120969-peer-reviews.pdf
Scientific Misconduct Check 120969-scientific-misconduct-check.png
CrossCheck Report 120969-crosscheck-report.pdf
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