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Articles Published Processes
1/27/2015 3:33:00 PM | Browse: 1090 | Download: 1506
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Received |
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2014-06-22 12:40 |
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Peer-Review Started |
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2014-06-22 18:07 |
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To Make the First Decision |
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2014-07-21 13:27 |
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Return for Revision |
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2014-07-28 15:39 |
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Revised |
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2014-08-22 15:08 |
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Second Decision |
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2014-09-30 09:58 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-09-30 10:17 |
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Articles in Press |
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2014-09-30 10:52 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-10-15 11:36 |
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Typeset the Manuscript |
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2015-01-15 18:03 |
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Publish the Manuscript Online |
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2015-01-27 15:33 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Loss of stromal caveolin-1 expression in colorectal cancer predicts poor survival
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi Zhao, Fang-Hai Han, Shi-Bin Yang, Li-Xin Hua, Jian-Hai Wu and Wen-Hua Zhan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81072049 |
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| Corresponding Author |
Fang-Hai Han, MD, Department of Gastrointestinal Surgery, the First Affiliated Hospital of Sun Yat-sen University, Zhongshan Road No. 2, Guangzhou 510080, Guangdong Province, China. fh_han@163.com |
| Key Words |
CAV-1; Stroma; Colorectal cancer; Prognosis |
| Core Tip |
Caveolin-1 (CAV-1), an essential structural protein of the endocytic caveolae plasma membrane, plays a major role in modulating tumorigenic processes. Recent studies have revealed that the loss of stromal CAV-1 results in an activated tumor microenvironment and is signi?cantly related to tumor recurrence and a poor prognosis for many tumors. However, the association between CAV-1 and colorectal cancer remains unknown. In our study, we observed CAV-1 expression in both tumor and stromal cells. Our results demonstrate that the loss of stromal CAV-1 is an independent predictor of poor overall survival and disease-free survival, whereas CAV-1 expression in tumor cells has no prognostic value. |
| Publish Date |
2015-01-27 15:33 |
| Citation |
Zhao Z, Han FH, Yang SB, Hua LX, Wu JH, Zhan WH. Loss of stromal caveolin-1 expression in colorectal cancer predicts poor survival. World J Gastroenterol 2015; 21(4): 1140-1147 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i4/1140.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i4.1140 |
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