Publication Name	World Journal of Gastroenterology
Manuscript ID	12101
Country	China

Received	2014-06-22 12:40
Peer-Review Started	2014-06-22 18:07
To Make the First Decision	2014-07-21 13:27
Return for Revision	2014-07-28 15:39
Revised	2014-08-22 15:08
Second Decision	2014-09-30 09:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-09-30 10:17
Articles in Press	2014-09-30 10:52
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-10-15 11:36
Typeset the Manuscript	2015-01-15 18:03
Publish the Manuscript Online	2015-01-27 15:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Loss of stromal caveolin-1 expression in colorectal cancer predicts poor survival
Manuscript Source	Unsolicited Manuscript
All Author List	Zhi Zhao, Fang-Hai Han, Shi-Bin Yang, Li-Xin Hua, Jian-Hai Wu and Wen-Hua Zhan
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81072049
Corresponding Author	Fang-Hai Han, MD, Department of Gastrointestinal Surgery, the First Affiliated Hospital of Sun Yat-sen University, Zhongshan Road No. 2, Guangzhou 510080, Guangdong Province, China. fh_han@163.com
Key Words	CAV-1; Stroma; Colorectal cancer; Prognosis
Core Tip	Caveolin-1 (CAV-1), an essential structural protein of the endocytic caveolae plasma membrane, plays a major role in modulating tumorigenic processes. Recent studies have revealed that the loss of stromal CAV-1 results in an activated tumor microenvironment and is signi?cantly related to tumor recurrence and a poor prognosis for many tumors. However, the association between CAV-1 and colorectal cancer remains unknown. In our study, we observed CAV-1 expression in both tumor and stromal cells. Our results demonstrate that the loss of stromal CAV-1 is an independent predictor of poor overall survival and disease-free survival, whereas CAV-1 expression in tumor cells has no prognostic value.
Publish Date	2015-01-27 15:33
Citation	Zhao Z, Han FH, Yang SB, Hua LX, Wu JH, Zhan WH. Loss of stromal caveolin-1 expression in colorectal cancer predicts poor survival. World J Gastroenterol 2015; 21(4): 1140-1147
URL	http://www.wjgnet.com/1007-9327/full/v21/i4/1140.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i4.1140

Full Article (PDF)	WJG-21-1140.pdf
Full Article (Word)	WJG-21-1140.doc
Manuscript File	12101-Review.docx
Answering Reviewers	12101-Answering reviewers.pdf
Copyright License Agreement	12101-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	12101-Language certificate.pdf
Peer-review Report	12101-Peer review(s).pdf
Scientific Misconduct Check	12101-CrossCheck.jpg
Scientific Editor Work List	12101-Scientific editor work list.pdf