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9/17/2026 5:48:23 AM | Browse: 0 | Download: 0
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Received |
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2026-03-13 02:51 |
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Peer-Review Started |
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2026-03-13 02:52 |
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First Decision by Editorial Office Director |
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2026-03-20 11:45 |
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Return for Revision |
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2026-03-22 00:59 |
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Revised |
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2026-07-16 00:30 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-08-28 02:55 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-08-28 09:12 |
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Articles in Press |
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2026-08-28 09:12 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-07 03:01 |
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Publish the Manuscript Online |
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2026-09-17 05:48 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Opinion Review |
| Article Title |
Rethinking metabolic risk in primary biliary cholangitis: The prognostic impact of lean type 2 diabetes mellitus
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Fernanda M Martínez-Díaz, Elsie A Jiménez-Cuevas, Mariana Montoya-López, Mariana M Ramírez-Mejía and Nahum Méndez-Sánchez |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Nahum Méndez-Sánchez, Liver Research Unit, Medica Sur Clinic and Foundation, Puente de Piedra 150, Col. Toriello Guerra, Mexico City 14050, Mexico. nmendez@medicasur.org.mx |
| Key Words |
Type 2 diabetes mellitus; Primary biliary cholangitis; Body mass index; Mortality; Metabolic dysfunction |
| Core Tip |
Primary biliary cholangitis presents marked clinical heterogeneity that is not fully explained by the current prognostic models. These models are primarily based on the biochemical response to ursodeoxycholic acid and the fibrosis stage. Emerging evidence suggests that metabolic dysfunction, particularly type 2 diabetes mellitus in lean individuals, is an underrecognized modifier of disease progression and mortality. Recent findings indicate synergistic adverse effects between the thin phenotype and diabetes, which challenges traditional body mass index-based assumptions regarding metabolic risk in patients with primary biliary cholangitis. Thus, beyond weight, comprehensive metabolic assessment should be incorporated into risk stratification strategies. In addition, future prospective studies should evaluate whether integrating lean type 2 diabetes mellitus into existing prognostic models can improve individualized patient management. |
| Publish Date |
2026-09-17 05:48 |
| Citation |
Martínez-Díaz FM, Jiménez-Cuevas EA, Montoya-López M, Ramírez-Mejía MM, Méndez-Sánchez N. Rethinking metabolic risk in primary biliary cholangitis: The prognostic impact of lean type 2 diabetes mellitus. World J Hepatol 2026; 18(9): 121019
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| URL |
https://www.wjgnet.com/1948-5182/full/v18/i9/121019.htm |
| DOI |
https://doi.org/10.4254/wjh.121019 |
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