BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
9/10/2026 12:49:02 AM | Browse: 2 | Download: 0
 |
Received |
|
2026-03-17 03:11 |
|
Peer-Review Started |
|
2026-03-17 03:13 |
|
First Decision by Editorial Office Director |
|
2026-04-03 09:27 |
|
Return for Revision |
|
2026-04-03 09:27 |
|
Revised |
|
2026-04-17 08:55 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2026-06-09 02:35 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-06-09 08:25 |
|
Articles in Press |
|
2026-06-09 08:25 |
|
Edit the Manuscript by Language Editor |
|
2026-06-15 22:02 |
|
Typeset the Manuscript |
|
2026-09-03 09:27 |
|
Publish the Manuscript Online |
|
2026-09-10 00:49 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Gut microbial metabolites as key mediators in inflammatory bowel disease
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Tatiana Sall, Ekaterina Litvinova, Elena Arzhanova, Stanislav Sitkin and Timur Vakhitov |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Russian Science Foundation |
No. 20-65-47026 |
|
| Corresponding Author |
Stanislav Sitkin, Associate Professor, Head, MD, PhD, Senior Researcher, Functional Metabolomics and Human Microbiome Research Group, Institute of Perinatology and Pediatrics, Almazov National Medical Research Centre, Akkuratova Street, 2, St. Petersburg 197341, Russia. drsitkin@gmail.com |
| Key Words |
Inflammatory bowel disease; Gut microbial metabolites; Butyrate; Propionate; Valerate; 2-Hydroxybutyrate; Synergistic regulatory activity; Dysbiosis; Microbe-host cross-talk; Metabiotic concept |
| Core Tip |
Gut microbial dysbiosis is a driving factor in inflammatory bowel disease (IBD) pathogenesis, mainly through a reduced capacity of the dysbiotic microbiota to synthesize beneficial metabolites, such as short-chain fatty acids, or through increased production of pathogenic metabolites, such as hydrogen sulfide, reactive nitrogen species, and lactate. We found elevated levels of 2-hydroxybutyric acid in Muc2−/− mice’s blood and revealed its ability to worsen IBD progression in the models of the disease. Butyric, propionic, and valeric acids, especially when used in combination, had a therapeutic effect in IBD through their anti-inflammatory and immunomodulatory potential and their gut microbiota-restoring properties. |
| Publish Date |
2026-09-10 00:49 |
| Citation |
Sall T, Litvinova E, Arzhanova E, Sitkin S, Vakhitov T. Gut microbial metabolites as key mediators in inflammatory bowel disease. World J Gastroenterol 2026; 32(39): 121041
|
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i39/121041.htm |
| DOI |
https://doi.org/10.3748/wjg.121041 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
