| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Minireviews |
| Article Title |
Genetic and biological determinants of pulmonary embolism: Insights from Mendelian randomization studies
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Rupak Desai, Darsh Patel, Abhishek Prasad, Navya Mandalapu, Jai Nagarajan, Ananth Guddeti, Sourabh Khatri, Warda Shahnawaz, Abdul Aleem, Adil S Mohammed, Umera Yasmeen and Muhammad Usman Ghani |
| ORCID |
|
| Funding Agency and Grant Number |
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| Corresponding Author |
Muhammad Usman Ghani, Assistant Professor, MD, Medicine, Central Michigan University College of Medicine, 1632 Stone St, Saginaw, MI 48602, United States. usmanghani162@gmail.com |
| Key Words |
Pulmonary embolism; Mendelian randomization; Matrix metalloproteinases; Immune dysregulation; Renal dysfunction; Genetic epidemiology; Thrombosis; Risk factors |
| Core Tip |
Mendelian randomization evidence indicates that matrix metalloproteinases (MMP)-19 may be associated with increased risk of pulmonary embolism (PE), while MMP-12 may exhibit an inverse association. Reduced kidney function appears to have a potential genetic association with PE susceptibility. Immune pathways involving HLA-DR-positive natural killer cell traits and gut microbiota-related factors, such as Clostridium innocuum, Butyricicoccus, and Actinobacteria, may also contribute to PE susceptibility. In contrast, no consistent associations were observed for type 2 diabetes mellitus, atrial fibrillation, or epigenetic age acceleration. These findings underscore emerging biological pathways in PE; however, they should be interpreted cautiously, as they are hypothesis-generating and require further validation. |
| Publish Date |
2026-06-16 08:10 |
| Citation |
Desai R, Patel D, Prasad A, Mandalapu N, Nagarajan J, Guddeti A, Khatri S, Shahnawaz W, Aleem A, Mohammed AS, Yasmeen U, Ghani MU. Genetic and biological determinants of pulmonary embolism: Insights from Mendelian randomization studies. World J Exp Med 2026; 16(2): 121046
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| URL |
https://www.wjgnet.com/2220-315X/full/v16/i2/121046.htm |
| DOI |
https://doi.org/10.5493/wjem.v16.i2.121046 |
