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Articles Published Processes
10/9/2026 4:02:30 AM | Browse: 1 | Download: 3
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Received |
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2026-03-16 03:37 |
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Peer-Review Started |
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2026-03-16 03:38 |
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First Decision by Editorial Office Director |
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2026-04-23 08:59 |
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Return for Revision |
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2026-04-23 08:59 |
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Revised |
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2026-04-28 10:26 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-26 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-26 06:12 |
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Articles in Press |
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2026-05-26 06:12 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-15 09:19 |
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Publish the Manuscript Online |
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2026-10-09 04:02 |
| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pediatrics |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Psychobiotics in pediatric autism spectrum disorder: A systematic review of efficacy, mechanisms, and clinical translation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mohammed Al-Beltagi, Nermin Kamal Saeed and Yousif M Elbeltagi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mohammed Al-Beltagi, Chairman, Consultant, Head, MD, PhD, Professor, Department of Pediatrics, Faculty of Medicine, Tanta University, 1 Hassan Radwan Street, Tanta 31511, Algharbia, Egypt. mbelrem@hotmail.com |
| Key Words |
Autism spectrum disorder; Psychobiotics; Probiotics; Prebiotics; Synbiotics; Fecal microbiota transplantation; Gut–brain axis, Children |
| Core Tip |
Microbiome-targeted therapies are emerging as promising adjunctive strategies for children with autism spectrum disorder, particularly in those with co-existing gastrointestinal disorders. We observed from this systematic review that probiotics and prebiotics consistently improve gastrointestinal symptom severity, while synbiotics may provide broader modulation of gut microbial ecology. Fecal microbiota transplantation induced the largest observed improvements in both gastrointestinal outcomes and selected behavioral domains, although current evidence is limited by small sample sizes and methodological heterogeneity. These findings support strong evidence that the microbiota-gut-brain axis is a biologically reasonable therapeutic target and highlight the need for large, well-designed randomized trials. |
| Publish Date |
2026-10-09 04:02 |
| Citation |
Al-Beltagi M, Saeed NK, Elbeltagi YM. Psychobiotics in pediatric autism spectrum disorder: A systematic review of efficacy, mechanisms, and clinical translation. World J Clin Pediatr 2026; 15(4): 121115
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| URL |
https://www.wjgnet.com/2219-2808/full/v15/i4/121115.htm |
| DOI |
https://doi.org/10.5409/wjcp.121115 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
