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8/5/2026 7:53:15 AM | Browse: 1 | Download: 0
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Received |
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2026-03-19 00:30 |
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Peer-Review Started |
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2026-03-19 23:57 |
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First Decision by Editorial Office Director |
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2026-04-23 05:52 |
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Return for Revision |
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2026-04-23 05:52 |
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Revised |
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2026-05-10 08:42 |
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Publication Fee Transferred |
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2026-05-25 15:10 |
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Second Decision by Editor |
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2026-07-03 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-07-03 06:08 |
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Articles in Press |
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2026-07-03 06:08 |
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Edit the Manuscript by Language Editor |
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2026-07-09 18:28 |
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Typeset the Manuscript |
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2026-07-27 09:21 |
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Publish the Manuscript Online |
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2026-08-05 07:53 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Maternally transmitted type 2 diabetes mellitus may be associated with mitochondrial tRNAThr mutations
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xue-Jiao Yu and Yu Ding |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Quzhou Bureau of Science and Technology |
No.2025K044 |
| Hangzhou Joint Fund of the Zhejiang Provincial Natural Science Foundation of China |
No. LHZY24H020002 |
| Hangzhou Municipal Health Commission |
No. ZD20220010 |
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| Corresponding Author |
Yu Ding, Associate Professor, MD, Department of Clinical Laboratory, Hangzhou First People’s Hospital, No. 261 Huansha Road, Hangzhou 310006, Zhejiang Province, China. dingyu_zj@126.com |
| Key Words |
Type 2 diabetes mellitus; Chinese pedigree; Mitochondrial tRNAThr; Mutations; Mitochondrial dysfunction |
| Core Tip |
This study identified three mitochondrial tRNAThr mutations – G15927A, G15930A, and A15951G – in two Han Chinese pedigrees with maternally transmitted type 2 diabetes mellitus. These mutations were associated with variable clinical phenotypes, including deafness, visual impairment, and renal failure. Functional analyses using cybrid cell lines revealed that these mutations lead to mitochondrial dysfunction, as evidenced by reduced adenosine triphosphate production, decreased mitochondrial membrane potential, lower NAD+/NADH ratio, and increased reactive oxygen species levels. Our findings highlighted tRNAThr as a mutational hotspot in mitochondrial diabetes and supported the inclusion of these mutations in genetic screening for early diagnosis and prevention of type 2 diabetes mellitus. |
| Publish Date |
2026-08-05 07:53 |
| Citation |
Yu XJ, Ding Y. Maternally transmitted type 2 diabetes mellitus may be associated with mitochondrial tRNAThr mutations. World J Diabetes 2026; 17(8): 121165
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| URL |
https://www.wjgnet.com/1948-9358/full/v17/i8/121165.htm |
| DOI |
https://doi.org/10.4239/wjd.121165 |
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