| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Ophthalmology |
| Manuscript Type |
Minireviews |
| Article Title |
Identifying and treating amiodarone-induced corneal deposits: When the heart saves and the cornea speaks
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Matteo Capobianco, Simonetta Gaia Nicolosi, Francesco Cappellani, Alessandro Avitabile, Ludovica Cannizaro, Federico Visalli, Fabiana D’Esposito, Irene Gattazzo, Caterina Gagliano and Marco Zeppieri |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Marco Zeppieri, Consultant, MD, PhD, Postdoc, Department of Ophthalmology, University Hospital of Udine, p. le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it |
| Key Words |
Amiodarone; Cornea verticillata; Drug-induced keratopathy; In vivo confocal microscopy; Ocular surface disease; Multidisciplinary management |
| Core Tip |
Amiodarone therapy is classically linked to cornea verticillata, a characteristic epithelial finding detected during routine ophthalmic examination. In many patients, these changes remain asymptomatic, but in some cases they may contribute to glare, halos, or more general visual discomfort, especially when pre-existing ocular surface disease is also present. Slit-lamp biomicroscopy remains the cornerstone of diagnosis, while anterior segment optical coherence tomography and, in selected cases, in vivo confocal microscopy may provide adjunctive structural documentation. Recognizing amiodarone-related corneal findings is clinically important, not only for accurate diagnosis, but also for appropriate patient counseling, symptom-oriented management, and rational follow-up planning. |
| Publish Date |
2026-06-18 09:51 |
| Citation |
Capobianco M, Nicolosi SG, Cappellani F, Avitabile A, Cannizaro L, Visalli F, D’Esposito F, Gattazzo I, Gagliano C, Zeppieri M. Identifying and treating amiodarone-induced corneal deposits: When the heart saves and the cornea speaks. World J Cardiol 2026; 18(6): 121185
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| URL |
https://www.wjgnet.com/1949-8462/full/v18/i6/121185.htm |
| DOI |
https://doi.org/10.4330/wjc.121185 |
