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Articles Published Processes
9/1/2026 6:22:41 AM | Browse: 1 | Download: 0
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Received |
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2026-03-20 13:41 |
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Peer-Review Started |
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2026-03-20 13:41 |
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First Decision by Editorial Office Director |
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2026-04-10 10:15 |
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Return for Revision |
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2026-04-10 10:15 |
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Revised |
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2026-04-25 09:23 |
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Publication Fee Transferred |
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2026-04-29 05:40 |
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Second Decision by Editor |
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2026-06-30 02:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-30 07:44 |
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Articles in Press |
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2026-06-30 07:44 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-21 07:48 |
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Publish the Manuscript Online |
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2026-09-01 06:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
This study demonstrated that Wenyang Jiedu Huayu Formula (WYJD) ameliorated acute-on-chronic liver failure by targeting succinate metabolism. WYJD acts partly through succinate dehydrogenase to clear accumulated succinate and suppress hypoxia-inducible factor-1α signaling, thereby correcting energy metabolic disturbances and attenuating macrophage-mediated inflammation. These findings suggested that succinate metabolism can be a potential therapeutic target in acute-on-chronic liver failure, and the study provided mechanistic insights supporting the clinical application of WYJD from a metabolic-immune perspective. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Wenyang Jiedu Huayu Formula targets succinate metabolism to alleviate acute-on-chronic liver failure
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jie Zhou, Xiao-Ling Tian, Yi-Fang Zhou, Zhuo-Yu Zhou, Nian-Hua Tan and Bin Chen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82575008 |
| Chinese Medicine Advantageous Disease (Clinical Evidence-Based Capacity Enhancement) Project of the National Administration of Traditional Chinese Medicine |
czxm-kyb-2025001 |
| Hunan Provincial Natural Science Foundation of China |
2026JJ30167, 2026JJ50326 |
| University-Hospital Joint Fund Project of Hunan University of Chinese Medicine |
2024XYLH343 |
| Hunan Provincial Postgraduate Research Innovation Project |
2024CX018 |
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| Corresponding Author |
Bin Chen, Department of Hepatology, The First Hospital of Hunan University of Chinese Medicine, No. 95 Shaoshan Middle Road, Yuhua District, Changsha 410007, Hunan Province, China. chenbin0410@126.com |
| Key Words |
Acute-on-chronic liver failure; Wenyang Jiedu Huayu Formula; Succinate metabolism; Succinate dehydrogenase; Hypoxia-inducible factor-1α; Macrophages; Metabolic reprogramming |
| Core Tip |
This study demonstrated that Wenyang Jiedu Huayu Formula (WYJD) ameliorated acute-on-chronic liver failure by targeting succinate metabolism. WYJD acts partly through succinate dehydrogenase to clear accumulated succinate and suppress hypoxia-inducible factor-1α signaling, thereby correcting energy metabolic disturbances and attenuating macrophage-mediated inflammation. These findings suggested that succinate metabolism can be a potential therapeutic target in acute-on-chronic liver failure, and the study provided mechanistic insights supporting the clinical application of WYJD from a metabolic-immune perspective. |
| Publish Date |
2026-09-01 06:22 |
| Citation |
Zhou J, Tian XL, Zhou YF, Zhou ZY, Tan NH, Chen B. Wenyang Jiedu Huayu Formula targets succinate metabolism to alleviate acute-on-chronic liver failure. World J Gastroenterol 2026; 32(37): 121244
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i37/121244.htm |
| DOI |
https://doi.org/10.3748/wjg.121244 |
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