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Articles Published Processes
10/9/2026 4:02:29 AM | Browse: 12 | Download: 151
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Received |
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2026-03-23 00:55 |
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Peer-Review Started |
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2026-03-23 00:57 |
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First Decision by Editorial Office Director |
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2026-04-04 02:37 |
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Return for Revision |
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2026-04-04 02:37 |
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Revised |
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2026-04-17 16:26 |
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Publication Fee Transferred |
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2026-04-20 08:24 |
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Second Decision by Editor |
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2026-05-19 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-19 08:16 |
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Articles in Press |
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2026-05-19 08:16 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-16 00:20 |
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Publish the Manuscript Online |
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2026-10-09 04:02 |
| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
UGT1A1-related disorders in Bahrain: A genetic and clinical overview of Crigler-Najjar and Gilbert syndromes
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hasan M Isa, Fatema A Abdulaal, Maryam Y Busehail, Maryam H Kamal, Hawra A Alaswad, Fatima Y Alshaikh, Aysha A Aljassmi and Anfal J Hijris |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hasan M Isa, Associate Professor, Consultant, Principal Investigator, Senior Researcher, Department of Pediatrics, College of Medicine and Medical Sciences, Arabian Gulf University, 2904 Al Salmaniya Area, Manama 26671, Bahrain. halfaraj@hotmail.com |
| Key Words |
Indirect hyperbilirubinemia; UGT1A1-related disorders; Crigler-Najjar syndrome; Gilbert syndrome; Bahrain |
| Core Tip |
This first study from Bahrain demonstrated that UGT1A1-related disorders represent important causes of persistent unconjugated hyperbilirubinemia, affecting 2.2 per 100000 individuals. Gilbert syndrome (GS) was the most common phenotype, followed by Crigler–Najjar syndrome (CNS) type I and type II. Early genetic testing is crucial for diagnosis, particularly in patients with parental consanguinity and those with associated hematological disorders, mainly glucose-6-phosphate dehydrogenase deficiency. Homozygous (TA)7/7 was the most common variant. CNS-I requires lifelong phototherapy or liver transplantation, whereas CNS-II is treated with phenobarbital; however, treatment adherence remains challenging. No treatment is required for GS. |
| Publish Date |
2026-10-09 04:02 |
| Citation |
Isa HM, Abdulaal FA, Busehail MY, Kamal MH, Alaswad HA, Alshaikh FY, Aljassmi AA, Hijris AJ. UGT1A1-related disorders in Bahrain: A genetic and clinical overview of Crigler-Najjar and Gilbert syndromes. World J Clin Pediatr 2026; 15(4): 121263
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| URL |
https://www.wjgnet.com/2219-2808/full/v15/i4/121263.htm |
| DOI |
https://doi.org/10.5409/wjcp.121263 |
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