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7/14/2026 9:35:00 AM | Browse: 2 | Download: 0
Publication Name World Journal of Gastroenterology
Manuscript ID 121267
Country China
Received
2026-03-20 13:30
Peer-Review Started
2026-03-20 13:32
First Decision by Editorial Office Director
2026-05-08 10:05
Return for Revision
2026-05-08 10:05
Revised
2026-06-02 12:21
Publication Fee Transferred
2026-06-08 05:55
Second Decision by Editor
2026-06-22 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-06-22 06:51
Articles in Press
2026-06-22 06:51
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-06-29 08:42
Publish the Manuscript Online
2026-07-14 09:35
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Observational Study
Article Title Diagnostic efficacy of fecal calprotectin combined with a high-sensitivity quantitative fecal immunochemical test for colorectal tumors
Manuscript Source Unsolicited Manuscript
All Author List Wei Jing, Lei Qin, Xiao-Han Zhang, Fei Pan, Rong-Rong Ren, Yan Li, Yan Zhang, Li-Hua Peng, Zi-Kai Wang and Xiu-Li Zhang
ORCID
Author(s) ORCID Number
Wei Jing http://orcid.org/0009-0002-9467-901X
Fei Pan http://orcid.org/0000-0002-3307-7931
Rong-Rong Ren http://orcid.org/0000-0001-7109-6271
Li-Hua Peng http://orcid.org/0000-0002-8549-6994
Zi-Kai Wang http://orcid.org/0000-0002-6293-7179
Xiu-Li Zhang http://orcid.org/0000-0002-6453-2394
Funding Agency and Grant Number
Corresponding Author Xiu-Li Zhang, Chief, MD, PhD, Microbiota Division, Department of Gastroenterology and Hepatology, The First Medical Center of Chinese People’s Liberation Army (PLA) General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. zhangxl70@126.com
Key Words Colorectal tumors; Colorectal cancer; Advanced adenoma; Fecal immunochemical test; Fecal calprotectin; Diagnostic efficiency
Core Tip Fecal calprotectin is a calcium-containing antimicrobial protein complex. Currently, it is primarily used in clinical practice for the diagnosis and monitoring of inflammatory bowel disease; however, its diagnostic value in colorectal tumors remains to be established. This paper draws a preliminary conclusion that fecal calprotectin can serve as a reliable biomarker for colorectal cancer. When combined with the fecal high-sensitivity quantitative immunochemical test, calprotectin increases the sensitivity for diagnosing colorectal cancer to 87.5%, raises the negative predictive value to 82.8%, and achieves an area under the receiver operating characteristic curve of 0.866. The combination of two biomarkers enhances the diagnostic efficacy for colorectal tumors.
Publish Date 2026-07-14 09:35
Citation

Jing W, Qin L, Zhang XH, Pan F, Ren RR, Li Y, Zhang Y, Peng LH, Wang ZK, Zhang XL. Diagnostic efficacy of fecal calprotectin combined with a high-sensitivity quantitative fecal immunochemical test for colorectal tumors. World J Gastroenterol 2026; 32(28): 121267

URL https://www.wjgnet.com/1007-9327/full/v32/i28/121267.htm
DOI https://doi.org/10.3748/wjg.121267
Full Article (PDF) WJG-32-121267-with-cover.pdf
STROBE Statement 121267-STROBE-statement.pdf
Manuscript File 121267_Auto_Edited_031801.docx
Answering Reviewers 121267-answering-reviewers.pdf
Audio Core Tip 121267-audio.mp3
Biostatistics Review Certificate 121267-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 121267-conflict-of-interest-statement.pdf
Copyright License Agreement 121267-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 121267-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 121267-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 121267-non-native-speakers.pdf
Peer-review Report 121267-peer-reviews.pdf
Scientific Misconduct Check 121267-scientific-misconduct-check.png
Scientific Editor Work List 121267-scientific-editor-work-list.pdf
CrossCheck Report 121267-crosscheck-report.pdf