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Articles Published Processes
8/11/2026 6:12:00 AM | Browse: 4 | Download: 0
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Received |
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2026-03-23 03:26 |
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Peer-Review Started |
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2026-03-23 03:27 |
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First Decision by Editorial Office Director |
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2026-04-23 09:49 |
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Return for Revision |
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2026-04-23 09:49 |
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Revised |
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2026-05-11 08:31 |
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Publication Fee Transferred |
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2026-05-20 08:09 |
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Second Decision by Editor |
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2026-06-22 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-22 06:46 |
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Articles in Press |
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2026-06-22 06:46 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-31 06:48 |
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Publish the Manuscript Online |
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2026-08-11 06:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Piezo mechanosensitive channels: A biological hub for intestinal barrier homeostasis and an emerging target for disease intervention
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu-You Bu, Xin Li, Tian-Yu Zhou, Jia-He Gu, Jia-Ning Zhu, Jia-Lu Li, Bin-Bin Zeng, Wei-Bing Zu and Dong Tang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Dong Tang, MD, PhD, Department of General Surgery, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, No. 98 Nantong West Road, Yangzhou 225000, Jiangsu Province, China. 83392785@qq.com |
| Key Words |
Intestinal barrier; Intestinal diseases; Mechanosensation; Piezo channel; Targeted therapy |
| Core Tip |
Piezo mechanical sensitive channel is the core mechanical transduction hub for maintaining intestinal homeostasis, which can convert mechanical force into biological signals. They regulate a complex network encompassing epithelial renewal, barrier integrity, immune response and gastrointestinal dynamics. Piezo channel dysfunction can directly drive the development of inflammatory bowel disease, irritable bowel syndrome and colon cancer. Therefore, the pharmacological regulation of the Piezo channels by using specific drugs such as the agonist Yoda1 or the inhibitor grammostola spatulata mechanosensitive channel toxin 4 can provide a promising treatment strategy for the intestinal diseases. |
| Publish Date |
2026-08-11 06:12 |
| Citation |
Bu YY, Li X, Zhou TY, Gu JH, Zhu JN, Li JL, Zeng BB, Zu WB, Tang D. Piezo mechanosensitive channels: A biological hub for intestinal barrier homeostasis and an emerging target for disease intervention. World J Gastroenterol 2026; 32(33): 121284
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i33/121284.htm |
| DOI |
https://doi.org/10.3748/wjg.121284 |
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