BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
6/17/2026 6:55:12 AM | Browse: 2 | Download: 1
Publication Name World Journal of Orthopedics
Manuscript ID 121358
Country China
Received
2026-03-24 03:06
Peer-Review Started
2026-03-24 03:07
First Decision by Editorial Office Director
2026-04-03 02:51
Return for Revision
2026-04-03 02:51
Revised
2026-04-18 11:29
Publication Fee Transferred
2026-04-22 10:24
Second Decision by Editor
2026-05-13 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-05-13 04:32
Articles in Press
2026-05-13 04:32
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-05-27 16:16
Publish the Manuscript Online
2026-06-17 06:55
ISSN 2218-5836 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Orthopedics
Manuscript Type Observational Study
Article Title Effects of hydrogen inhalation duration on symptom relief in elderly patients with knee osteoarthritis: A pilot study
Manuscript Source Unsolicited Manuscript
All Author List Chen-Hui Wang, Yu-Ru Li, Lei Han, Hong-Qian Wang, Shu-Feng Jia, Xing-Chen Liu, Hao Wu, Fan Wu and Bao-Guo Wang
ORCID
Author(s) ORCID Number
Bao-Guo Wang http://orcid.org/0000-0001-6879-8491
Funding Agency and Grant Number
Funding Agency Grant Number
Capital’s Funds for Health Improvement and Research CFH2024-3-8011
Corresponding Author Bao-Guo Wang, Chief Physician, MD, Professor, Department of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, No. 36 Courtyard, Dongba Middle Road, Chaoyang District, Beijing 100018, China. wangbg@ccmu.edu.cn
Key Words Hydrogen; Elderly; Osteoarthritis; Dose-response relationship; Non-pharmacological management
Core Tip This pilot study is the first to demonstrate a dose-response relationship between cumulative hydrogen inhalation duration and symptom relief in elderly patients with knee osteoarthritis. Long-term inhalation (over 30 cumulative hours) provided significantly greater improvements in pain, stiffness, and physical function than short-term inhalation. The therapeutic benefit followed a logarithmic curve, plateauing after approximately 114 cumulative hours, suggesting a potential saturation point for clinical efficacy.
Publish Date 2026-06-17 06:55
Citation

Wang CH, Li YR, Han L, Wang HQ, Jia SF, Liu XC, Wu H, Wu F, Wang BG. Effects of hydrogen inhalation duration on symptom relief in elderly patients with knee osteoarthritis: A pilot study. World J Orthop 2026; 17(6): 121358

URL https://www.wjgnet.com/2218-5836/full/v17/i6/121358.htm
DOI https://doi.org/10.5312/wjo.v17.i6.121358
Full Article (PDF) WJO-17-121358-with-cover.pdf
STROBE Statement 121358-STROBE-statement.pdf
Manuscript File 121358_Auto_Edited_092018.docx
Answering Reviewers 121358-answering-reviewers.pdf
Audio Core Tip 121358-audio.m4a
Biostatistics Review Certificate 121358-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 121358-conflict-of-interest-statement.pdf
Copyright License Agreement 121358-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 121358-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 121358-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 121358-non-native-speakers.pdf
Peer-review Report 121358-peer-reviews.pdf
Scientific Misconduct Check 121358-scientific-misconduct-check.png
Scientific Editor Work List 121358-scientific-editor-work-list.pdf
CrossCheck Report 121358-crosscheck-report.pdf