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9/10/2026 12:49:02 AM | Browse: 2 | Download: 0
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Received |
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2026-03-24 01:19 |
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Peer-Review Started |
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2026-03-24 01:24 |
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First Decision by Editorial Office Director |
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2026-04-15 08:23 |
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Return for Revision |
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2026-04-15 08:23 |
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Revised |
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2026-04-17 04:51 |
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Publication Fee Transferred |
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2026-04-23 10:08 |
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Second Decision by Editor |
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2026-06-05 03:10 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-05 08:13 |
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Articles in Press |
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2026-06-05 08:13 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-03 00:26 |
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Publish the Manuscript Online |
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2026-09-10 00:49 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Comparative efficacy and pharmacological heterogeneity of individual potassium-competitive acid blockers: A systematic review and network meta-analysis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Eun Jeong Gong, Chang Seok Bang, Jae Jun Lee and Gwang Ho Baik |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) |
No. RS-2023-00223501 |
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| Corresponding Author |
Chang Seok Bang, MD, PhD, Department of Internal Medicine, Hallym University College of Medicine, Sakju-ro 77, Chuncheon 24253, Gangwon-do, South Korea. cloudslove@naver.com |
| Key Words |
Potassium-competitive acid blocker; Vonoprazan; Tegoprazan; Acid dissociation constant; Helicobacter pylori; Erosive esophagitis |
| Core Tip |
Potassium-competitive acid blockers (P-CABs) suppress acid faster and more consistently than proton pump inhibitors. Over 30 meta-analyses pooled all P-CABs as a single class. Guidelines treat individual P-CABs as interchangeable. Individual P-CABs differ substantially in clinical outcomes, suggesting that efficacy may not be uniform across the class. Acid dissociation constant (pKa) values showed a positive correlation with clinical efficacy, with high-pKa P-CABs (vonoprazan, keverprazan) achieving 82%-84% eradication in clarithromycin-resistant Helicobacter pylori vs 47.8% for low-pKa tegoprazan. However, fexuprazan (pKa of 9.04) did not follow this pattern, demonstrating that pKa alone is insufficient to predict outcomes. The pKa may be one contributing factor but is not sufficient alone. Multiple pharmacological properties likely contribute to antisecretory effectiveness and clinical outcomes. These findings generate the hypothesis that pKa may inform P-CAB selection, particularly for clarithromycin-resistant infection and severe esophagitis, pending prospective validation. |
| Publish Date |
2026-09-10 00:49 |
| Citation |
Gong EJ, Bang CS, Lee JJ, Baik GH. Comparative efficacy and pharmacological heterogeneity of individual potassium-competitive acid blockers: A systematic review and network meta-analysis. World J Gastroenterol 2026; 32(39): 121372
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i39/121372.htm |
| DOI |
https://doi.org/10.3748/wjg.121372 |
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