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7/27/2026 9:36:19 AM | Browse: 1 | Download: 0
Publication Name World Journal of Gastrointestinal Surgery
Manuscript ID 121387
Country China
Received
2026-03-24 03:29
Peer-Review Started
2026-03-24 03:31
First Decision by Editorial Office Director
2026-04-10 05:52
Return for Revision
2026-04-10 05:52
Revised
2026-04-14 04:05
Publication Fee Transferred
2026-04-29 08:08
Second Decision by Editor
2026-05-22 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-05-22 04:13
Articles in Press
2026-05-22 04:13
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-07-09 08:18
Publish the Manuscript Online
2026-07-27 09:36
ISSN 1948-9366 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Study
Article Title Ziwu-Liuzhu-guided combined external therapy promotes wound healing in postoperative perianal fistulizing Crohn’s disease
Manuscript Source Unsolicited Manuscript
All Author List Shao-Yan Zhao, Shi-Jie Ma, Chen-Xi Ouyang, Shi-Lin Zhu and Xiang-Bin Xiao
ORCID
Author(s) ORCID Number
Shi-Lin Zhu http://orcid.org/0009-0004-4868-3776
Funding Agency and Grant Number
Funding Agency Grant Number
Hunan Provincial Traditional Chinese Medicine Scientific Research Project No. 20255711
Corresponding Author Shi-Lin Zhu, Researcher, Department of Nursing, The Second Affiliated Hospital of Hunan University of Chinese Medicine, No. 233 Caie North Road, Kaifu District, Changsha 410007, Hunan Province, China. lin_6359s@163.com
Key Words Perianal fistulizing Crohn’s disease; Ziwu-Liuzhu; External traditional Chinese medicine therapy; Wound healing; Inflammatory response; Anxiety status
Core Tip Perianal fistulizing Crohn’s disease (PFCD) is difficult to manage after surgery because delayed wound healing and persistent inflammation are common. In this retrospective cohort study, a Ziwu-Liuzhu-guided time-specific traditional Chinese medicine external therapy was associated with better postoperative recovery than sitz bath alone or non-time-specific combined therapy. Patients in the time-specific group showed faster wound healing, lower inflammatory marker levels, greater improvement in Crohn’s Disease Activity Index and Perianal Disease Activity Index scores, and better anxiety outcomes. These findings suggest that treatment timing may be an important adjunct in integrated postoperative PFCD management.
Publish Date 2026-07-27 09:36
Citation

Zhao SY, Ma SJ, Ouyang CX, Zhu SL, Xiao XB. Ziwu-Liuzhu-guided combined external therapy promotes wound healing in postoperative perianal fistulizing Crohn’s disease. World J Gastrointest Surg 2026; 18(7): 121387

URL https://www.wjgnet.com/1948-9366/full/v18/i7/121387.htm
DOI https://doi.org/10.4240/wjgs.v18.i7.121387
Full Article (PDF) WJGS-18-121387-with-cover.pdf
Manuscript File 121387_Auto_Edited_082522.docx
Answering Reviewers 121387-answering-reviewers.pdf
Audio Core Tip 121387-audio.mp3
Biostatistics Review Certificate 121387-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 121387-conflict-of-interest-statement.pdf
Copyright License Agreement 121387-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 121387-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 121387-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 121387-non-native-speakers.pdf
Peer-review Report 121387-peer-reviews.pdf
Scientific Misconduct Check 121387-scientific-misconduct-check.png
Scientific Editor Work List 121387-scientific-editor-work-list.pdf
CrossCheck Report 121387-crosscheck-report.pdf