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9/11/2026 6:09:11 AM | Browse: 1 | Download: 0
Publication Name World Journal of Meta-Analysis
Manuscript ID 121388
Country India
Received
2026-03-24 03:34
Peer-Review Started
2026-03-24 03:35
First Decision by Editorial Office Director
2026-04-30 08:52
Return for Revision
2026-04-30 14:56
Revised
2026-05-12 16:33
Publication Fee Transferred
Second Decision by Editor
2026-06-23 02:17
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-06-23 07:09
Articles in Press
2026-06-23 07:09
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-09-08 00:21
Publish the Manuscript Online
2026-09-11 06:09
ISSN 2308-3840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Dentistry, Oral Surgery & Medicine
Manuscript Type Systematic Reviews
Article Title Gut microbiota axis in periodontitis: A systematic review and meta-analysis of inflammatory and microbial interactions
Manuscript Source Invited Manuscript
All Author List Neelam Das
ORCID
Author(s) ORCID Number
Neelam Das http://orcid.org/0000-0002-5812-3471
Funding Agency and Grant Number
Corresponding Author Neelam Das, Associate Professor, Department of Periodontology, Sri Sai College of Dental Surgery, 1-2-64/1 and 2, Kothrepally, Alampally, Vikarabad 501102, Telangana, India. dasneelam423@gmail.com
Key Words Periodontitis; Gut microbiota; Dysbiosis; Systemic inflammation; Microbial diversity; Host immune response; Systematic review; Meta-analysis
Core Tip This updated systematic review and meta-analysis up to January 2026 shows that gut microbiota dysbiosis is associated with increased periodontal disease severity. Reduced microbial diversity, altered Firmicutes to Bacteroidetes ratio, enrichment of pro inflammatory taxa, and depletion of short chain fatty acid producing bacteria were consistently observed. These changes correlated with elevated systemic inflammatory markers and worse periodontal clinical parameters. The findings support the role of the gut microbiota axis in periodontal disease and highlight its potential relevance for future diagnostic and therapeutic strategies.
Publish Date 2026-09-11 06:09
Citation

Das N. Gut microbiota axis in periodontitis: A systematic review and meta-analysis of inflammatory and microbial interactions. World J Meta-Anal 2026; 14(3): 121388

URL https://www.wjgnet.com/2308-3840/full/v14/i3/121388.htm
DOI https://doi.org/10.13105/wjma.121388
Full Article (PDF) WJMA-14-121388-with-cover.pdf
PRISMA 2009 Checklist 121388-PRISMA-2009-Checklist.pdf
Manuscript File 121388_Auto_Edited_031032.docx
Answering Reviewers 121388-answering-reviewers.pdf
Audio Core Tip 121388-audio.mp3
Biostatistics Review Certificate 121388-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 121388-conflict-of-interest-statement.pdf
Copyright License Agreement 121388-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 121388-non-native-speakers.pdf
Supplementary Material 121388-supplementary-material.pdf
Peer-review Report 121388-peer-reviews.pdf
Scientific Misconduct Check 121388-scientific-misconduct-check.png
CrossCheck Report 121388-crosscheck-report.pdf