Publication Name	World Journal of Gastroenterology
Manuscript ID	12140
Country	Croatia

Received	2014-06-24 08:29
Peer-Review Started	2014-06-25 15:27
First Decision by Editorial Office Director
Return for Revision	2014-09-30 09:14
Revised	2014-10-22 16:32
Publication Fee Transferred
Second Decision by Editor	2014-11-10 16:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-11-19 09:19
Articles in Press	2014-11-19 09:43
Edit the Manuscript by Language Editor	2014-12-02 18:23
Typeset the Manuscript	2014-12-16 15:14
Publish the Manuscript Online	2015-01-06 09:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Sanja Stojsavljević, Marija Gomerčić Palčić, Lucija Virović Jukić, Lea Smirčić Duvnjak and Marko Duvnjak
Funding Agency and Grant Number
Corresponding Author	Marko Duvnjak, MD, PhD, Professor, Chief, Department of Gastroenterology and Hepatology, Clinic of Internal medicine, Clinical hospital center “Sestre milosrdnice’’, Vinogradska cesta 29, 10000 Zagreb, Croatia. marko.duvnjak1@gmail.com
Key Words	Nonalcoholic fatty liver disease; Cytokines; Adipokines; Adiponectin; Leptin; Tumor necrosis factor-a; Interleukin-6; Interleukin-1; Interleukin-18; Ghrelin
Core Tip	The pathogenesis of nonalcoholic fatty liver disease (NAFLD) is still not fully elucidated. We explored the role of the following adipocytokines and proinflammatory cytokines in the pathogenesis of NAFLD: adiponectin, leptin, ghrelin, resistin and visfatin among adipokines, and tumor necrosis factor-? (TNF-?), interleukin (IL)-6 and IL-1 among proinflammatory cytokines. Although a definite conclusion is complex, from analyzed data we could conclude that adiponectin, des-acyl ghrelin and leptin are adipokines that decrease, while TNF-? and IL-6 are cytokines that enhance insulin resistance and subsequently NAFLD. Acting on these premises, new therapeutic possibilities emerge; however, much work remains to be done.
Publish Date	2015-01-06 09:08
Citation	Stojsavljević S, Gomerčić Palčić M, Virović Jukić L, Smirčić Duvnjak L, Duvnjak M. Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease. World J Gastroenterol 2014; 20(48): 18070-18091
URL	http://www.wjgnet.com/1007-9327/full/v20/i48/18070.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i48.18070

Full Article (PDF)	WJG-20-18070.pdf
Full Article (Word)	WJG-20-18070.doc
Manuscript File	12140-Review.doc
Answering Reviewers	12140-Answering reviewerw.pdf
Copyright License Agreement	12140-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	12140-Language certificate.pdf
Peer-review Report	12140-Peer review(s).pdf
Scientific Misconduct Check	12140-CrossCheck.jpg
Scientific Editor Work List	12140-Scientific editor work list.pdf