| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Activated cGAS-STING signaling promotes malignancy in metabolic dysfunction-associated fatty liver disease via mitochondrial DNA and immune cell dysfunction
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Meng-Ya Zhou, Rong-Fei Fang, Hao Tang, Xiao-Xiao Xia, Qun Xie, Deng-Fu Yao, Wen-Li Sai and Min Yao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation |
No. 32470985 |
| Nantong Science and Technology Programs |
No. MS2024051 |
| Nantong Control of Infectious Diseases |
No. NTCRB2025016 |
| Nantong Health Commission of China |
No. QN2025064 |
|
| Corresponding Author |
Min Yao, PhD, Postdoc, Professor, Vice Director, Department of Immunology, Medical School of Nantong University, Nantong University, No. 19 Qixiu Road, Nantong 226001, Jiangsu Province, China. erbei@ntu.edu.cn |
| Key Words |
Metabolic dysfunction-associated fatty liver disease; Cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes; Hepatocellular carcinoma; Mitochondrial damage; Single-cell sequencing |
| Core Tip |
Hepatocyte cyclic guanosine monophosphate-adenosine monophosphate synthase, as a DNA sensor, recognizes damaged mitochondrial DNA with aberrant lipid metabolism to activate stimulator of interferon genes to trigger the expressions of inflammatory factors, such as type-I interferon, which might be closely related to metabolic dysfunction-associated fatty liver disease (MAFLD) progression. However, the molecular mechanisms underlying MAFLD malignancy are still unclear. In this study, the activation of the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes signaling pathway was systematically evaluated in a lipid accumulation model, and the pathogenesis of MAFLD was clarified by evaluating the interactions among hepatocyte injury, inflammatory factors, and immune cells in hepatocarcinogenesis. |
| Publish Date |
2026-07-24 07:03 |
| Citation |
Zhou MY, Fang RF, Tang H, Xia XX, Xie Q, Yao DF, Sai WL, Yao M. Activated cGAS-STING signaling promotes malignancy in metabolic dysfunction-associated fatty liver disease via mitochondrial DNA and immune cell dysfunction. World J Hepatol 2026; 18(7): 121423
|
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i7/121423.htm |
| DOI |
https://doi.org/10.4254/wjh.121423 |
