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Articles Published Processes
9/9/2026 9:45:13 AM | Browse: 4 | Download: 0
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Received |
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2026-03-26 03:49 |
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Peer-Review Started |
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2026-03-26 03:49 |
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First Decision by Editorial Office Director |
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2026-04-04 02:13 |
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Return for Revision |
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2026-04-04 02:13 |
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Revised |
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2026-04-17 09:19 |
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Publication Fee Transferred |
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2026-04-21 09:18 |
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Second Decision by Editor |
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2026-06-01 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-02 07:10 |
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Articles in Press |
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2026-06-02 07:10 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-21 09:26 |
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Publish the Manuscript Online |
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2026-09-09 09:45 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Spatial transcriptomics reveals tumor niche heterogeneity in advanced gastric cancer and suggests a tumor-promoting role for KRT6B
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Rui Ni, Hui Dong, Rui-Dong Han, Xue-Chen Ren, Yu-Ling Qu, Lei Wang, Shen-Si Chen and You-Cheng Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation project of Ningxia |
No. 2023AAC03680 |
| Ningxia Medical University Research Project |
No. XM2020166 |
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| Corresponding Author |
You-Cheng Zhang, MD, PhD, Professor, Laboratory of Hepatic-Biliary-Pancreatic, Department of General Surgery, Second Hospital and Clinical Medical School, Lanzhou University, No. 82 Cuiying Gate, Chengguan District, Lanzhou 730030, Gansu Province, China. zhangychmd@126.com |
| Key Words |
Gastric cancer; Spatial transcriptomics; Stereo-seq; Spatial heterogeneity; KRT6B |
| Core Tip |
The spatial organization of advanced gastric cancer remains insufficiently characterized. Using full-thickness Stereo-seq profiling, this study identified a superficial-to-deep tumor niche axis, niche-specific transcriptional gradients, and a spatially isolated tumor nest with preferential enrichment for KRT6B. External validation and in vitro assays further supported KRT6B as a candidate molecule associated with aggressive tumor phenotypes. Although the study was based on a limited number of samples, these findings provide an initial spatial framework for investigating intratumoral heterogeneity in advanced gastric cancer. |
| Publish Date |
2026-09-09 09:45 |
| Citation |
Ni R, Dong H, Han RD, Ren XC, Qu YL, Wang L, Chen SS, Zhang YC. Spatial transcriptomics reveals tumor niche heterogeneity in advanced gastric cancer and suggests a tumor-promoting role for KRT6B. World J Gastrointest Oncol 2026; 18(9): 121446
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i9/121446.htm |
| DOI |
https://doi.org/10.4251/wjgo.121446 |
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